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1
2018 - 07 - 05
doi.org/10.1038/s41586-018-0162-7基于20年的深入研究,得克薩斯大學西南醫(yī)學中心(UT Southwestern)自噬研究中心的主任Beth Levine和團隊已經(jīng)明確:細胞自噬可以延長壽命、改善健康。他們以小鼠為模型發(fā)現(xiàn),自噬水平提高的小鼠壽命更長、更健康?!熬唧w來說,它們的壽命延長了約10%,且不太可能發(fā)生與年齡相關的自發(fā)性癌癥、心臟病等疾病?!盉eth Levine表示道。細胞自噬自噬是一種保護機制。當細胞內(nèi)出現(xiàn)衰老的蛋白質(zhì)、損壞的細胞器等廢棄物時,自噬囊泡會將它們包裹并送至溶酶體中進行降解并得以循環(huán)利用,從而確保細胞本身的代謝需求和某些細胞器的更新。細胞自噬過程(圖片來源:華威大學)20年前,Beth Levine和同事發(fā)現(xiàn)了自噬生物學過程中的一個關鍵基因beclin 1。他們還發(fā)現(xiàn),自噬對于健康而言必不可少,例如預防神經(jīng)衰退性疾病、對抗癌癥和感染。2003年,Beth Levine團隊證實,自噬關聯(lián)的基因機制對于長壽突變線蟲(long-lived mutant roundworms)的壽命延長至關重要?!皬哪且院?,關于‘自噬是延長壽命的關鍵機制’的觀點尤為火熱?!?Beth Levine解釋道,“隨著年齡增長,細胞的自噬能力會下降,這可能會導致衰老?!弊允裳娱L壽命然而,一個關鍵問題仍然沒有得到解答:增強自噬水平是否有益于哺乳動物的健康?換句...
2
2019 - 05 - 06
來源: 中國科學報年初,一部電視劇《都挺好》火遍全國,大結(jié)局時劇中一直讓人恨得牙癢癢的 “作爹” 蘇大強,因患上了阿爾茨海默氏癥(AD,俗稱老年癡呆癥)而成功“洗白”,惹出了不少人的眼淚。阿爾茨海默氏癥離我們并不遙遠,由它引發(fā)的故事也是常有耳聞,大多伴隨著無奈與辛酸。隨著全球老齡化進程的加快,愈來愈多的阿爾茨海默氏癥患者將給家屬及社會帶來沉重的負擔。根據(jù)國際阿爾茨海默氏病協(xié)會的統(tǒng)計數(shù)據(jù),2018 年全世界有 5000 萬老人患有癡呆,每 3 秒鐘,就有 1 位患者產(chǎn)生;中國是阿爾茨海默氏病的重災區(qū),估計有 1000 萬患者。關于阿爾茨海默氏癥發(fā)病機制和治療方法的研究一直都是科研界關注的重點之一。近日,中國科學院昆明動物研究所姚永剛課題組在阿爾茨海默氏癥的治療研究上取得重要進展,該研究闡明了核受體過氧化物酶體α激動劑吉非羅齊和匹立尼酸的抗阿爾茨海默氏癥分子機制。相關論文在線發(fā)表于《自噬》(Autophagy)雜志上。誘導自噬,清除 Aβ作為發(fā)生在老年前期與老年期的一種常見的神經(jīng)退行性腦病,阿爾茨海默氏癥是最常見的老年癡呆類型,其發(fā)病率隨著年齡增長而顯著增加。其臨床表現(xiàn)為病人漸進性記憶喪失、認知能力下降并伴有焦慮等其他精神相關癥狀。對于阿爾茨海默氏癥的發(fā)病機制,現(xiàn)有很多學說,其中影響最廣泛的有β- 淀粉樣蛋白(β-amyloid,Aβ)瀑布理論,認為 Aβ的生成與清除失衡是導致神經(jīng)元變...
3
2019 - 09 - 05
2016年《消失的微生物》一書問世,腸道微生態(tài)研究走入大眾視野,目前全球范圍內(nèi)針對微生物與肥胖、哮喘、過敏、糖尿病、腫瘤、精神類疾病的研究正逐步開展。一、腸道微生物概況人體是由自身細胞及共生的大量微生物細胞所共同組成的復雜共生生命體。目前研究認為人體腸道內(nèi)聚集的微生物數(shù)目可達1012~1014個,是人體自身細胞數(shù)目的10倍,微生物包含的基因數(shù)目超過987萬個,人類自身基因數(shù)只有2萬個左右,是人體自身基因數(shù)目的幾百倍,這些后天獲得的共生菌群及其所攜帶的遺傳及分子信息即可稱為微生物組。(一)人體腸道微生物是如何建立的?有研究表明,人體在出生成長過程中,主要在兩個重要的環(huán)節(jié)、以兩種不同的方式實現(xiàn)對腸道菌群的塑造。第一個環(huán)節(jié)是在分娩過程,嬰兒會從母親產(chǎn)道獲得健康的腸道菌群,剖腹產(chǎn)和孕期抗生素則會改變正常嬰兒菌群的建立。另一個環(huán)節(jié)則是出生后的哺乳及斷奶后的膳食干預。在女性乳腺中存在著乳酸菌等系列微生物,這些微生物在哺乳過程中進入并定植于嬰兒腸道。隨著哺乳期的結(jié)束,日趨豐富的膳食外源營養(yǎng)物質(zhì)則長期調(diào)節(jié)著人體腸道微生物中的的變化。(二)腸道微生物對人體健康有何影響?腸道菌群與人體互利共生,依靠人體沒有消化的食物殘渣和腸道分泌的黏液和脫落的死細胞作為營養(yǎng)來維持很高的種群水平?;钴S生長的腸道菌群會產(chǎn)生大量的活性物質(zhì),同時包括短鏈脂肪酸、維生素和抗氧化等有益健康的產(chǎn)物,以及神經(jīng)毒素、致癌物質(zhì)和免疫毒素...
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產(chǎn)品名稱:

EVOS? 10X Objective, fluorite, LWD

上市日期: 2019-04-11
產(chǎn)品類別: EVOS

規(guī)格

For Use With (Equipment):EVOS? FL Auto Imaging System,?EVOS? FL Color Imaging System,?EVOS? FL Imaging System
Lens Type:Plan Fluorite
Magnification:10X
Product Line:EVOS?
Product Size:1 each
Quantity:1 each
Type:Objective Lens


  • 產(chǎn)品描述
  • 產(chǎn)品功能
  • 產(chǎn)品參數(shù)

描述

This fluorite objective is ideal for fluorescence and demanding transmitted-light applications. This is a long working distance (LWD) objective that is optimized for the imaging of slides, cell culture dishes and flasks, and microtiter plates. All EVOS? objectives offer outstanding optical performance from visible light to near infrared light. The extensive choice of objectives satisfies needs across the spectrum of magnifications and optical specifications.

Additional characteristics of this EVOS? objective:

? Magnification: 10X
? Numerical Aperture: 0.30
? Working Distance: 8.3 mm

Image Quality
Microscope objectives may be the most important components of an optical microscope because they are responsible for primary image formation. Image quality is crucial to experimental success and a requirement for publication; EVOS? objectives afford that quality across the visible spectrum to near infrared light. This performance results from years of lens manufacture perfection. EVOS? objectives have the same or better numerical apertures as any other manufacturer's in the same class, and the broad selection means you have choices for your imaging requirements.

Objective Classes

Achromat objectives are perfect for general applications, with standard correction of color and focus.

Fluorite objectives deliver excellent resolution and are made with higher numerical apertures than achromat objectives, resulting in brighter fluorescence signal and higher contrast imaging. The higher optical quality greatly reduces optical aberrations, and corrections for color and focus are at higher levels than achromat objectives. Fluorite objectives are ideally suited for fluorescence and demanding transmitted light applications, where the higher contrast make them ideally suited for color imaging.

Apochromat objectives are manufactured to the highest levels of resolution, fluorescence brightness, and contrast; chromatic aberrations are almost eliminated. They are recommended for the most demanding applications, particularly at magnifications of 60x and above. Apochromatic objectives are the best choice for the capture of color images in white light.

Brightfield Contrast versus Phase Contrast Objectives
Brightfield is the most basic form of light microscopy and is accomplished by sample absorption of light. A higher density area in a sample will absorb more light, thus increasing contrast in those areas.

Phase contrast objectives are most useful for hard to see, translucent specimens. This method of contrast is accomplished by converting phase shifts, caused by light passing through a translucent specimen, into brightness changes (i.e., contrast).

Long Working Distance versus Coverslip-Corrected Objectives
Long working distance (LWD) objectives are optimized for use through vessels with a nominal wall thickness of 0.9-1.5 mm. This includes vessels commonly used in cell culture and cell-based assays, such as slides, cell culture dishes and flasks, microtiter well plates, etc. Coverslip-corrected objectives are optimized for use through #1.5 coverslips (thickness approximately 0.17 mm). These objectives have a higher magnification/NA ratio and provide higher resolution compared to LWD objectives.

For additional choices, visit the EVOS? Objectives selection guide
Explore the entire EVOS? line of imaging systems and accessories


規(guī)格

For Use With (Equipment):EVOS? FL Auto Imaging System,?EVOS? FL Color Imaging System,?EVOS? FL Imaging System
Lens Type:Plan Fluorite
Magnification:10X
Product Line:EVOS?
Product Size:1 each
Quantity:1 each
Type:Objective Lens


規(guī)格

For Use With (Equipment):EVOS? FL Auto Imaging System,?EVOS? FL Color Imaging System,?EVOS? FL Imaging System
Lens Type:Plan Fluorite
Magnification:10X
Product Line:EVOS?
Product Size:1 each
Quantity:1 each
Type:Objective Lens


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