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1
2018 - 07 - 05
doi.org/10.1038/s41586-018-0162-7基于20年的深入研究,得克薩斯大學(xué)西南醫(yī)學(xué)中心(UT Southwestern)自噬研究中心的主任Beth Levine和團(tuán)隊(duì)已經(jīng)明確:細(xì)胞自噬可以延長(zhǎng)壽命、改善健康。他們以小鼠為模型發(fā)現(xiàn),自噬水平提高的小鼠壽命更長(zhǎng)、更健康?!熬唧w來(lái)說(shuō),它們的壽命延長(zhǎng)了約10%,且不太可能發(fā)生與年齡相關(guān)的自發(fā)性癌癥、心臟病等疾病?!盉eth Levine表示道。細(xì)胞自噬自噬是一種保護(hù)機(jī)制。當(dāng)細(xì)胞內(nèi)出現(xiàn)衰老的蛋白質(zhì)、損壞的細(xì)胞器等廢棄物時(shí),自噬囊泡會(huì)將它們包裹并送至溶酶體中進(jìn)行降解并得以循環(huán)利用,從而確保細(xì)胞本身的代謝需求和某些細(xì)胞器的更新。細(xì)胞自噬過(guò)程(圖片來(lái)源:華威大學(xué))20年前,Beth Levine和同事發(fā)現(xiàn)了自噬生物學(xué)過(guò)程中的一個(gè)關(guān)鍵基因beclin 1。他們還發(fā)現(xiàn),自噬對(duì)于健康而言必不可少,例如預(yù)防神經(jīng)衰退性疾病、對(duì)抗癌癥和感染。2003年,Beth Levine團(tuán)隊(duì)證實(shí),自噬關(guān)聯(lián)的基因機(jī)制對(duì)于長(zhǎng)壽突變線蟲(chóng)(long-lived mutant roundworms)的壽命延長(zhǎng)至關(guān)重要?!皬哪且院螅P(guān)于‘自噬是延長(zhǎng)壽命的關(guān)鍵機(jī)制’的觀點(diǎn)尤為火熱?!?Beth Levine解釋道,“隨著年齡增長(zhǎng),細(xì)胞的自噬能力會(huì)下降,這可能會(huì)導(dǎo)致衰老?!弊允裳娱L(zhǎng)壽命然而,一個(gè)關(guān)鍵問(wèn)題仍然沒(méi)有得到解答:增強(qiáng)自噬水平是否有益于哺乳動(dòng)物的健康?換句...
2
2019 - 05 - 06
來(lái)源: 中國(guó)科學(xué)報(bào)年初,一部電視劇《都挺好》火遍全國(guó),大結(jié)局時(shí)劇中一直讓人恨得牙癢癢的 “作爹” 蘇大強(qiáng),因患上了阿爾茨海默氏癥(AD,俗稱(chēng)老年癡呆癥)而成功“洗白”,惹出了不少人的眼淚。阿爾茨海默氏癥離我們并不遙遠(yuǎn),由它引發(fā)的故事也是常有耳聞,大多伴隨著無(wú)奈與辛酸。隨著全球老齡化進(jìn)程的加快,愈來(lái)愈多的阿爾茨海默氏癥患者將給家屬及社會(huì)帶來(lái)沉重的負(fù)擔(dān)。根據(jù)國(guó)際阿爾茨海默氏病協(xié)會(huì)的統(tǒng)計(jì)數(shù)據(jù),2018 年全世界有 5000 萬(wàn)老人患有癡呆,每 3 秒鐘,就有 1 位患者產(chǎn)生;中國(guó)是阿爾茨海默氏病的重災(zāi)區(qū),估計(jì)有 1000 萬(wàn)患者。關(guān)于阿爾茨海默氏癥發(fā)病機(jī)制和治療方法的研究一直都是科研界關(guān)注的重點(diǎn)之一。近日,中國(guó)科學(xué)院昆明動(dòng)物研究所姚永剛課題組在阿爾茨海默氏癥的治療研究上取得重要進(jìn)展,該研究闡明了核受體過(guò)氧化物酶體α激動(dòng)劑吉非羅齊和匹立尼酸的抗阿爾茨海默氏癥分子機(jī)制。相關(guān)論文在線發(fā)表于《自噬》(Autophagy)雜志上。誘導(dǎo)自噬,清除 Aβ作為發(fā)生在老年前期與老年期的一種常見(jiàn)的神經(jīng)退行性腦病,阿爾茨海默氏癥是最常見(jiàn)的老年癡呆類(lèi)型,其發(fā)病率隨著年齡增長(zhǎng)而顯著增加。其臨床表現(xiàn)為病人漸進(jìn)性記憶喪失、認(rèn)知能力下降并伴有焦慮等其他精神相關(guān)癥狀。對(duì)于阿爾茨海默氏癥的發(fā)病機(jī)制,現(xiàn)有很多學(xué)說(shuō),其中影響最廣泛的有β- 淀粉樣蛋白(β-amyloid,Aβ)瀑布理論,認(rèn)為 Aβ的生成與清除失衡是導(dǎo)致神經(jīng)元變...
3
2019 - 09 - 05
2016年《消失的微生物》一書(shū)問(wèn)世,腸道微生態(tài)研究走入大眾視野,目前全球范圍內(nèi)針對(duì)微生物與肥胖、哮喘、過(guò)敏、糖尿病、腫瘤、精神類(lèi)疾病的研究正逐步開(kāi)展。一、腸道微生物概況人體是由自身細(xì)胞及共生的大量微生物細(xì)胞所共同組成的復(fù)雜共生生命體。目前研究認(rèn)為人體腸道內(nèi)聚集的微生物數(shù)目可達(dá)1012~1014個(gè),是人體自身細(xì)胞數(shù)目的10倍,微生物包含的基因數(shù)目超過(guò)987萬(wàn)個(gè),人類(lèi)自身基因數(shù)只有2萬(wàn)個(gè)左右,是人體自身基因數(shù)目的幾百倍,這些后天獲得的共生菌群及其所攜帶的遺傳及分子信息即可稱(chēng)為微生物組。(一)人體腸道微生物是如何建立的?有研究表明,人體在出生成長(zhǎng)過(guò)程中,主要在兩個(gè)重要的環(huán)節(jié)、以?xún)煞N不同的方式實(shí)現(xiàn)對(duì)腸道菌群的塑造。第一個(gè)環(huán)節(jié)是在分娩過(guò)程,嬰兒會(huì)從母親產(chǎn)道獲得健康的腸道菌群,剖腹產(chǎn)和孕期抗生素則會(huì)改變正常嬰兒菌群的建立。另一個(gè)環(huán)節(jié)則是出生后的哺乳及斷奶后的膳食干預(yù)。在女性乳腺中存在著乳酸菌等系列微生物,這些微生物在哺乳過(guò)程中進(jìn)入并定植于嬰兒腸道。隨著哺乳期的結(jié)束,日趨豐富的膳食外源營(yíng)養(yǎng)物質(zhì)則長(zhǎng)期調(diào)節(jié)著人體腸道微生物中的的變化。(二)腸道微生物對(duì)人體健康有何影響?腸道菌群與人體互利共生,依靠人體沒(méi)有消化的食物殘?jiān)湍c道分泌的黏液和脫落的死細(xì)胞作為營(yíng)養(yǎng)來(lái)維持很高的種群水平?;钴S生長(zhǎng)的腸道菌群會(huì)產(chǎn)生大量的活性物質(zhì),同時(shí)包括短鏈脂肪酸、維生素和抗氧化等有益健康的產(chǎn)物,以及神經(jīng)毒素、致癌物質(zhì)和免疫毒素...
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產(chǎn)品名稱(chēng):

EVOS? 4X Objective, achromat, LWD, phase-contrast

上市日期: 2019-04-11
產(chǎn)品類(lèi)別: EVOS

規(guī)格

For Use With (Equipment):EVOS? FL Auto Imaging System,?EVOS? FL Color Imaging System,?EVOS? FL Imaging System,?EVOS? XL Core Imaging System,?EVOS? XL Imaging System
Lens Type:Plan Achromat
Magnification:4X
Product Line:EVOS?
Product Size:1 each
Quantity:1 each
Type:Objective Lens


  • 產(chǎn)品描述
  • 產(chǎn)品功能
  • 產(chǎn)品參數(shù)

描述

This achromat objective is ideal for general applications. This is a long working distance (LWD) objective that is optimized for the imaging of slides, cell culture dishes and flasks, and microtiter plates. This is also a phase-contrast objective, making it useful for hard-to-see, translucent speciments. All EVOS? objectives offer outstanding optical performance from visible light to near infrared light. The extensive choice of objectives satisfies needs across the spectrum of magnifications and optical specifications.

Additional characteristics of this EVOS? objective:

? Magnification: 4X
? Numerical Aperture: 0.13
? Working Distance: 16.9 mm

Image Quality
Microscope objectives may be the most important components of an optical microscope because they are responsible for primary image formation. Image quality is crucial to experimental success and a requirement for publication; EVOS? objectives afford that quality across the visible spectrum to near infrared light. This performance results from years of lens manufacture perfection. EVOS? objectives have the same or better numerical apertures as any other manufacturer's in the same class, and the broad selection means you have choices for your imaging requirements.

Objective Classes

Achromat objectives are perfect for general applications, with standard correction of color and focus.

Fluorite objectives deliver excellent resolution and are made with higher numerical apertures than achromat objectives, resulting in brighter fluorescence signal and higher contrast imaging. The higher optical quality greatly reduces optical aberrations, and corrections for color and focus are at higher levels than achromat objectives. Fluorite objectives are ideally suited for fluorescence and demanding transmitted light applications, where the higher contrast make them ideally suited for color imaging.

Apochromat objectives are manufactured to the highest levels of resolution, fluorescence brightness, and contrast; chromatic aberrations are almost eliminated. They are recommended for the most demanding applications, particularly at magnifications of 60x and above. Apochromatic objectives are the best choice for the capture of color images in white light.

Brightfield Contrast versus Phase Contrast Objectives
Brightfield is the most basic form of light microscopy and is accomplished by sample absorption of light. A higher density area in a sample will absorb more light, thus increasing contrast in those areas.

Phase contrast objectives are most useful for hard to see, translucent specimens. This method of contrast is accomplished by converting phase shifts, caused by light passing through a translucent specimen, into brightness changes (i.e., contrast).

Long Working Distance versus Coverslip-Corrected Objectives
Long working distance (LWD) objectives are optimized for use through vessels with a nominal wall thickness of 0.9-1.5 mm. This includes vessels commonly used in cell culture and cell-based assays, such as slides, cell culture dishes and flasks, microtiter well plates, etc. Coverslip-corrected objectives are optimized for use through #1.5 coverslips (thickness approximately 0.17 mm). These objectives have a higher magnification/NA ratio and provide higher resolution compared to LWD objectives.

For additional choices, visit the EVOS? Objectives selection guide
Explore the entire EVOS? line of imaging systems and accessories


規(guī)格

For Use With (Equipment):EVOS? FL Auto Imaging System,?EVOS? FL Color Imaging System,?EVOS? FL Imaging System,?EVOS? XL Core Imaging System,?EVOS? XL Imaging System
Lens Type:Plan Achromat
Magnification:4X
Product Line:EVOS?
Product Size:1 each
Quantity:1 each
Type:Objective Lens


規(guī)格

For Use With (Equipment):EVOS? FL Auto Imaging System,?EVOS? FL Color Imaging System,?EVOS? FL Imaging System,?EVOS? XL Core Imaging System,?EVOS? XL Imaging System
Lens Type:Plan Achromat
Magnification:4X
Product Line:EVOS?
Product Size:1 each
Quantity:1 each
Type:Objective Lens


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