97精品国自产拍在线观看_美日韩中文字幕_狠狠色丁香婷婷综合影院_h片欧美精品一区二区_一级毛片破过处的美女_亚洲AV有幕在线天堂动漫_无码专区白嫩少妇高潮喷水久久_皮特影院在线观看_热九九这里只有精品_亚洲综合网天天x

產(chǎn)品中心 Products
最新新聞 / News More
1
2018 - 07 - 05
doi.org/10.1038/s41586-018-0162-7基于20年的深入研究,得克薩斯大學(xué)西南醫(yī)學(xué)中心(UT Southwestern)自噬研究中心的主任Beth Levine和團隊已經(jīng)明確:細胞自噬可以延長壽命、改善健康。他們以小鼠為模型發(fā)現(xiàn),自噬水平提高的小鼠壽命更長、更健康?!熬唧w來說,它們的壽命延長了約10%,且不太可能發(fā)生與年齡相關(guān)的自發(fā)性癌癥、心臟病等疾病。”Beth Levine表示道。細胞自噬自噬是一種保護機制。當(dāng)細胞內(nèi)出現(xiàn)衰老的蛋白質(zhì)、損壞的細胞器等廢棄物時,自噬囊泡會將它們包裹并送至溶酶體中進行降解并得以循環(huán)利用,從而確保細胞本身的代謝需求和某些細胞器的更新。細胞自噬過程(圖片來源:華威大學(xué))20年前,Beth Levine和同事發(fā)現(xiàn)了自噬生物學(xué)過程中的一個關(guān)鍵基因beclin 1。他們還發(fā)現(xiàn),自噬對于健康而言必不可少,例如預(yù)防神經(jīng)衰退性疾病、對抗癌癥和感染。2003年,Beth Levine團隊證實,自噬關(guān)聯(lián)的基因機制對于長壽突變線蟲(long-lived mutant roundworms)的壽命延長至關(guān)重要?!皬哪且院螅P(guān)于‘自噬是延長壽命的關(guān)鍵機制’的觀點尤為火熱?!?Beth Levine解釋道,“隨著年齡增長,細胞的自噬能力會下降,這可能會導(dǎo)致衰老?!弊允裳娱L壽命然而,一個關(guān)鍵問題仍然沒有得到解答:增強自噬水平是否有益于哺乳動物的健康?換句...
2
2019 - 05 - 06
來源: 中國科學(xué)報年初,一部電視劇《都挺好》火遍全國,大結(jié)局時劇中一直讓人恨得牙癢癢的 “作爹” 蘇大強,因患上了阿爾茨海默氏癥(AD,俗稱老年癡呆癥)而成功“洗白”,惹出了不少人的眼淚。阿爾茨海默氏癥離我們并不遙遠,由它引發(fā)的故事也是常有耳聞,大多伴隨著無奈與辛酸。隨著全球老齡化進程的加快,愈來愈多的阿爾茨海默氏癥患者將給家屬及社會帶來沉重的負擔(dān)。根據(jù)國際阿爾茨海默氏病協(xié)會的統(tǒng)計數(shù)據(jù),2018 年全世界有 5000 萬老人患有癡呆,每 3 秒鐘,就有 1 位患者產(chǎn)生;中國是阿爾茨海默氏病的重災(zāi)區(qū),估計有 1000 萬患者。關(guān)于阿爾茨海默氏癥發(fā)病機制和治療方法的研究一直都是科研界關(guān)注的重點之一。近日,中國科學(xué)院昆明動物研究所姚永剛課題組在阿爾茨海默氏癥的治療研究上取得重要進展,該研究闡明了核受體過氧化物酶體α激動劑吉非羅齊和匹立尼酸的抗阿爾茨海默氏癥分子機制。相關(guān)論文在線發(fā)表于《自噬》(Autophagy)雜志上。誘導(dǎo)自噬,清除 Aβ作為發(fā)生在老年前期與老年期的一種常見的神經(jīng)退行性腦病,阿爾茨海默氏癥是最常見的老年癡呆類型,其發(fā)病率隨著年齡增長而顯著增加。其臨床表現(xiàn)為病人漸進性記憶喪失、認知能力下降并伴有焦慮等其他精神相關(guān)癥狀。對于阿爾茨海默氏癥的發(fā)病機制,現(xiàn)有很多學(xué)說,其中影響最廣泛的有β- 淀粉樣蛋白(β-amyloid,Aβ)瀑布理論,認為 Aβ的生成與清除失衡是導(dǎo)致神經(jīng)元變...
3
2019 - 09 - 05
2016年《消失的微生物》一書問世,腸道微生態(tài)研究走入大眾視野,目前全球范圍內(nèi)針對微生物與肥胖、哮喘、過敏、糖尿病、腫瘤、精神類疾病的研究正逐步開展。一、腸道微生物概況人體是由自身細胞及共生的大量微生物細胞所共同組成的復(fù)雜共生生命體。目前研究認為人體腸道內(nèi)聚集的微生物數(shù)目可達1012~1014個,是人體自身細胞數(shù)目的10倍,微生物包含的基因數(shù)目超過987萬個,人類自身基因數(shù)只有2萬個左右,是人體自身基因數(shù)目的幾百倍,這些后天獲得的共生菌群及其所攜帶的遺傳及分子信息即可稱為微生物組。(一)人體腸道微生物是如何建立的?有研究表明,人體在出生成長過程中,主要在兩個重要的環(huán)節(jié)、以兩種不同的方式實現(xiàn)對腸道菌群的塑造。第一個環(huán)節(jié)是在分娩過程,嬰兒會從母親產(chǎn)道獲得健康的腸道菌群,剖腹產(chǎn)和孕期抗生素則會改變正常嬰兒菌群的建立。另一個環(huán)節(jié)則是出生后的哺乳及斷奶后的膳食干預(yù)。在女性乳腺中存在著乳酸菌等系列微生物,這些微生物在哺乳過程中進入并定植于嬰兒腸道。隨著哺乳期的結(jié)束,日趨豐富的膳食外源營養(yǎng)物質(zhì)則長期調(diào)節(jié)著人體腸道微生物中的的變化。(二)腸道微生物對人體健康有何影響?腸道菌群與人體互利共生,依靠人體沒有消化的食物殘渣和腸道分泌的黏液和脫落的死細胞作為營養(yǎng)來維持很高的種群水平?;钴S生長的腸道菌群會產(chǎn)生大量的活性物質(zhì),同時包括短鏈脂肪酸、維生素和抗氧化等有益健康的產(chǎn)物,以及神經(jīng)毒素、致癌物質(zhì)和免疫毒素...
聯(lián)系我們
北京照生行儀器設(shè)備有限公司
銷售熱線:010-62929079
公司總機:010-62929079
圖文傳真:010-62929277
總部地址:北京市海淀區(qū)西二旗西路熱力公司院內(nèi)泰禾文化園二層
產(chǎn)品名稱:

EVOS? Light Cube, RFP

上市日期: 2019-04-12
產(chǎn)品類別: EVOS

規(guī)格

Excitation?Emission (nm):Ex: 531/40 Em: 593/40
For Use With (Equipment):Countess? II FL Automated Cell Counter,?EVOS? FL Auto Imaging System,?EVOS? FL Color Imaging System,?EVOS? FL Imaging System
Product Line:EVOS?
Product Size:1 each
Quantity:1 each
Type:LED Light Cube


  • 產(chǎn)品描述
  • 產(chǎn)品功能
  • 產(chǎn)品參數(shù)

描述

All EVOS? fluorescence imaging systems and the Countess? II FL Automated Cell Counter contain our unique, proprietary LED light cubes. This world-leading light engine outputs remarkable intensity over a short light path that delivers superior fluorophore excitation. Each cube contains an LED, condensing optics, and hard-coated filters. EVOS? light cubes are user-changeable and automatically recognized by the system. The RFP light cube is ideal for use with Alexa Fluor? 555, CellMask? Orange, pHrodo?, RFP, SYTOX? Orange and other fluorophores with excitation and emission maxima near 531 and 593 nm.

EVOS? light cubes offers you these important advantages:

? A shorter light path that affords superior detection of fluorescent signals
? Continuous illumination that enables consistent results
? A 50,000+ hour bulb lifetime that affords lower operating costs
? Adjustable light intensity that helps reduce photobleaching

Revolutionary Light Path
By placing the LED light cube as close as possible to the objective turret, the number of optical elements in the light path is minimized. High-intensity illumination over a short light path increases the efficiency of fluorophore excitation, providing better detection of weak fluorescent signals.

Continuous Light Intensity
Mercury arc lamps can decrease in intensity by 50% in the first 100 hours of operation—plus, images acquired in different sessions cannot be quantitatively compared using mercury illumination without complicated calibrations. Because EVOS? systems have continuous light cube intensity, users can rely on consistent illumination and can compare quantitative results from images acquired on different days. Each light cube contains a precisely matched set of optical components to optimize the position, evenness, and intensity of the light beam. Digitally controlled LED light sources allow adjustment of illumination levels, dramatically improving control over photobleaching.

Less Expensive to Own and Maintain
The LED bulbs on the EVOS? systems are rated for >50,000 hours (~17 years), compared to 300 hours for a typical mercury bulb and 1,500 hours for a metal halide bulb. This translates to savings in the overall upkeep of your instrument.

EVOS? Hard-coated Filter Sets for Higher Transmission Efficiencies
Hard-coated filter sets are more expensive that soft-coated filters, but they have sharper edges and significantly higher transmission efficiencies that typically result in >25% more light transmission than traditional soft-coated filters. With the EVOS? systems' hard-coated filter sets, your light cubes cost less over time. Plus, you will have brighter fluorescence, higher transmission efficiencies, the ability to detect faint fluorescence signals, and better signal-to-noise ratios.?


規(guī)格

Excitation?Emission (nm):Ex: 531/40 Em: 593/40
For Use With (Equipment):Countess? II FL Automated Cell Counter,?EVOS? FL Auto Imaging System,?EVOS? FL Color Imaging System,?EVOS? FL Imaging System
Product Line:EVOS?
Product Size:1 each
Quantity:1 each
Type:LED Light Cube


規(guī)格

Excitation?Emission (nm):Ex: 531/40 Em: 593/40
For Use With (Equipment):Countess? II FL Automated Cell Counter,?EVOS? FL Auto Imaging System,?EVOS? FL Color Imaging System,?EVOS? FL Imaging System
Product Line:EVOS?
Product Size:1 each
Quantity:1 each
Type:LED Light Cube


推薦新聞
地址:中國·上?!て謻|區(qū)-浦東新區(qū)康橋路787號5號樓159室
電話:021-64396663
Copyright@ 2015-2016 北京照生行儀器設(shè)備有限公司
傳真:+86 0755-2788 8009
郵編:330520