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1
2018 - 07 - 05
doi.org/10.1038/s41586-018-0162-7基于20年的深入研究,得克薩斯大學(xué)西南醫(yī)學(xué)中心(UT Southwestern)自噬研究中心的主任Beth Levine和團隊已經(jīng)明確:細胞自噬可以延長壽命、改善健康。他們以小鼠為模型發(fā)現(xiàn),自噬水平提高的小鼠壽命更長、更健康?!熬唧w來說,它們的壽命延長了約10%,且不太可能發(fā)生與年齡相關(guān)的自發(fā)性癌癥、心臟病等疾病?!盉eth Levine表示道。細胞自噬自噬是一種保護機制。當細胞內(nèi)出現(xiàn)衰老的蛋白質(zhì)、損壞的細胞器等廢棄物時,自噬囊泡會將它們包裹并送至溶酶體中進行降解并得以循環(huán)利用,從而確保細胞本身的代謝需求和某些細胞器的更新。細胞自噬過程(圖片來源:華威大學(xué))20年前,Beth Levine和同事發(fā)現(xiàn)了自噬生物學(xué)過程中的一個關(guān)鍵基因beclin 1。他們還發(fā)現(xiàn),自噬對于健康而言必不可少,例如預(yù)防神經(jīng)衰退性疾病、對抗癌癥和感染。2003年,Beth Levine團隊證實,自噬關(guān)聯(lián)的基因機制對于長壽突變線蟲(long-lived mutant roundworms)的壽命延長至關(guān)重要。“從那以后,關(guān)于‘自噬是延長壽命的關(guān)鍵機制’的觀點尤為火熱?!?Beth Levine解釋道,“隨著年齡增長,細胞的自噬能力會下降,這可能會導(dǎo)致衰老?!弊允裳娱L壽命然而,一個關(guān)鍵問題仍然沒有得到解答:增強自噬水平是否有益于哺乳動物的健康?換句...
2
2019 - 05 - 06
來源: 中國科學(xué)報年初,一部電視劇《都挺好》火遍全國,大結(jié)局時劇中一直讓人恨得牙癢癢的 “作爹” 蘇大強,因患上了阿爾茨海默氏癥(AD,俗稱老年癡呆癥)而成功“洗白”,惹出了不少人的眼淚。阿爾茨海默氏癥離我們并不遙遠,由它引發(fā)的故事也是常有耳聞,大多伴隨著無奈與辛酸。隨著全球老齡化進程的加快,愈來愈多的阿爾茨海默氏癥患者將給家屬及社會帶來沉重的負擔(dān)。根據(jù)國際阿爾茨海默氏病協(xié)會的統(tǒng)計數(shù)據(jù),2018 年全世界有 5000 萬老人患有癡呆,每 3 秒鐘,就有 1 位患者產(chǎn)生;中國是阿爾茨海默氏病的重災(zāi)區(qū),估計有 1000 萬患者。關(guān)于阿爾茨海默氏癥發(fā)病機制和治療方法的研究一直都是科研界關(guān)注的重點之一。近日,中國科學(xué)院昆明動物研究所姚永剛課題組在阿爾茨海默氏癥的治療研究上取得重要進展,該研究闡明了核受體過氧化物酶體α激動劑吉非羅齊和匹立尼酸的抗阿爾茨海默氏癥分子機制。相關(guān)論文在線發(fā)表于《自噬》(Autophagy)雜志上。誘導(dǎo)自噬,清除 Aβ作為發(fā)生在老年前期與老年期的一種常見的神經(jīng)退行性腦病,阿爾茨海默氏癥是最常見的老年癡呆類型,其發(fā)病率隨著年齡增長而顯著增加。其臨床表現(xiàn)為病人漸進性記憶喪失、認知能力下降并伴有焦慮等其他精神相關(guān)癥狀。對于阿爾茨海默氏癥的發(fā)病機制,現(xiàn)有很多學(xué)說,其中影響最廣泛的有β- 淀粉樣蛋白(β-amyloid,Aβ)瀑布理論,認為 Aβ的生成與清除失衡是導(dǎo)致神經(jīng)元變...
3
2019 - 09 - 05
2016年《消失的微生物》一書問世,腸道微生態(tài)研究走入大眾視野,目前全球范圍內(nèi)針對微生物與肥胖、哮喘、過敏、糖尿病、腫瘤、精神類疾病的研究正逐步開展。一、腸道微生物概況人體是由自身細胞及共生的大量微生物細胞所共同組成的復(fù)雜共生生命體。目前研究認為人體腸道內(nèi)聚集的微生物數(shù)目可達1012~1014個,是人體自身細胞數(shù)目的10倍,微生物包含的基因數(shù)目超過987萬個,人類自身基因數(shù)只有2萬個左右,是人體自身基因數(shù)目的幾百倍,這些后天獲得的共生菌群及其所攜帶的遺傳及分子信息即可稱為微生物組。(一)人體腸道微生物是如何建立的?有研究表明,人體在出生成長過程中,主要在兩個重要的環(huán)節(jié)、以兩種不同的方式實現(xiàn)對腸道菌群的塑造。第一個環(huán)節(jié)是在分娩過程,嬰兒會從母親產(chǎn)道獲得健康的腸道菌群,剖腹產(chǎn)和孕期抗生素則會改變正常嬰兒菌群的建立。另一個環(huán)節(jié)則是出生后的哺乳及斷奶后的膳食干預(yù)。在女性乳腺中存在著乳酸菌等系列微生物,這些微生物在哺乳過程中進入并定植于嬰兒腸道。隨著哺乳期的結(jié)束,日趨豐富的膳食外源營養(yǎng)物質(zhì)則長期調(diào)節(jié)著人體腸道微生物中的的變化。(二)腸道微生物對人體健康有何影響?腸道菌群與人體互利共生,依靠人體沒有消化的食物殘渣和腸道分泌的黏液和脫落的死細胞作為營養(yǎng)來維持很高的種群水平?;钴S生長的腸道菌群會產(chǎn)生大量的活性物質(zhì),同時包括短鏈脂肪酸、維生素和抗氧化等有益健康的產(chǎn)物,以及神經(jīng)毒素、致癌物質(zhì)和免疫毒素...
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產(chǎn)品名稱:

EVOS? M7000 Imaging System

上市日期: 2019-04-15
產(chǎn)品類別: EVOS

規(guī)格

Detection Method:Chromogenic,?Fluorescent
Product Line:EVOS?
Product Size:1 system
Shipping Condition:Room Temperature


  • 產(chǎn)品描述
  • 產(chǎn)品功能
  • 產(chǎn)品參數(shù)

描述

The EVOS M7000 Imaging System is a high-performance, fully automated, inverted, multi-channel fluorescence and transmitted light imaging system. It was developed to meet today’s expectations for image quality, user interface interactions, data generation speed and flexibility, and end-user value. The powerful and time-saving acquisition tools with enhanced autofocus algorithms and automated routines for microwell plate assays, time-lapse live cell imaging, area scanning in time lapse and Z-stacks in scan mode, and a superb optomechanical design enable the generation of publication-quality images and data with just a few clicks when and where needed.

The EVOS M7000 Imaging System offers these advantages:
? Outstanding image quality and versatility with a 5-position objective turret, 4-color LED fluorescence and transmitted light channels, and 3.2 MP CMOS color and B/W cameras
? Exceptional usability with fully automated X/Y scanning stage, autofocus, and acquisition routines
? High-speed image acquisition coupled with multi-position well scanning, and Z-stack and tile-stitch options lend power and flexibility to your data generation
? Fully integrated time-lapse live cell imaging using the optional EVOS Onstage Incubator for precise control of temperature, gases for normoxic or hypoxic conditions, and humidity
? Powerful image analysis capabilities for cell segmentation and quantification with the optional Celleste? Image Analysis Software

Fully automated imaging system
The EVOS M7000 system combines and integrates precision components with a unique modern design functionality that enables high-quality automated fluorescence imaging anywhere with unprecedented workflow efficiency. Full automation of the precision X/Y-stage movement; changing of the 4 LED fluorescent light cubes, 5-position objective turret, focus, and exposure; and switching of the dual camera make the EVOS M7000 system an exceptional platform for a variety of demanding imaging applications. Through the intuitive acquisition interface, you can program the EVOS M7000 system to run well-plate scanning, time lapse experiments, and tile-stitch/montage area scans in Z-stack and/or time-lapse modes in your vessel of choice. For live cell imaging over multiple hours or days, the optional EVOS Onstage Incubator, which functions as an environmental chamber on top of the microscope stage, is operated seamlessly from within the instrument interface. The EVOS M7000 system is compatible with all accessories for the predecessor EVOS FL Auto imaging system.

Versatile and highly configurable
With a 5-position objective turret and the ability to simultaneous acquire images in four fluorescence channels plus transmitted light, the optical system can be easily configured to meet your needs. Choose from our broad range of high quality coverslip-corrected and long-working-distance objectives for use with plastic vessels or glass sides. Available from 1.25X to 100X magnification in achromat, fluorite, or apochromat models, together with over twenty LED light cubes, the sample imaging options are limitless. Dual monochrome and color high-sensitivity dual CMOS cameras enable seamless imaging of both fluorescent and chromogenically stained samples. Interchangeable vessel holders accommodate most vessel types and sizes, including slides, multi-well plates, culture flasks, and Petri dishes, and afford precise control and sample alignment by the automated stage. The vessel creation wizard in the user interface enables creation of profiles for custom sample vessels.

Powerful software
The EVOS M7000 software presents users with an extensive suite of tools for acquisition, visualization, and analysis. The user interface was designed with a strong emphasis on usability, including an option to view samples in a single field mode (Field View) or in a window that covers a much larger area (Area View). By using a zoom function, the Area View size can be adjusted. A user can explore a large sample area at low magnification, define regions of interest, and then seamlessly transition to the Scan function in Automate Mode and execute an area scan at higher magnification.

The enhanced power of the EVOS M7000 system enables more demanding automated acquisition routines like area scanning in time lapse and Z-stacks in scan mode to be performed. Visualization capabilities include multi-field image viewing gallery, mosaic tiling and tile stitching options, Z-stack visualization, and a video recording and movie maker/editor for time lapse sequences. The EVOS M7000 system is fully compatible with the EVOS Onstage Incubator environmental chamber for control of temperature, gases, and humidity. With the ability generate both hypoxic and normoxic conditions, it is possible to study live cells over extended periods with highly flexible time lapse automation routines.

For users needing more powerful image analysis capabilities, images acquired on the EVOS M7000 system can be analyzed directly using the optional Celleste Image Analysis Software. Celleste software offers powerful tools for image segmentation and classification that can be applied to a range of cell analysis applications for counting and measuring intensity, area, and shape changes over time, and more.

Smart LED illumination technology
All EVOS fluorescence imaging systems utilize our proprietary LED light cubes. This light engine outputs remarkable intensity over a short light path and delivers incomparable fluorophore excitation. Each light cube contains a precisely matched set of optical components to optimize the position, evenness, and intensity of the light beam. Digitally controlled LED light sources allow adjustment of illumination levels to the sample and experimental conditions to minimize the risk of photo-toxicity and photo-bleaching in time-lapse studies. Hard-coated filters give sharper edges and significantly higher transmission efficiencies than traditional soft-coated filters.

Easy to use and reliable
The EVOS M7000 Imaging System is powerful, yet offers the simplicity of plug-and-play. Like other EVOS systems, it requires no warm-up or cool-down periods. The LED light source guarantees exceptional stability and durability, so you can turn the unit on and off whenever you need to image a sample. The environmentally safe, mercury-free LED bulbs are rated for >50,000 hours, compared to 300 hours for a typical mercury bulb and 1,500 hours for a metal halide bulb. The long lifetime and low energy consumption translate into significantly lower operating costs compared to instruments with conventional light sources. The EVOS M7000 system is powered by an external Dell PC with an Intel Core i7-8700 processor, 32 GB DDR4 RAM, 512 GB PCIe SSD, and NVIDIA Quadro P1000 with 4 GB discrete video graphics running Windows 10, designed to operate with touchscreen monitor and microscope. Whether acquiring single images or setting up automated routines, the EVOS M7000 system is remarkably easy to use and run. The 1920 x 1080 pixel resolution 23' LCD touch screen monitor enables “finger swipes” to expand or zoom in on images, and moving between microwell plate wells is done by a single touch. Operation is also also fully controllable via mouse.

The EVOS imaging systems are built from the ground up to maximize performance and optimize workflow. You will be astonished at how easy it is to operate and amazed at how extraordinary your images look on-screen.

Explore the entire EVOS line of imaging systems, accessories, and offers ?

System and hardware specifications
Optics: infinity‐corrected optical system; RMS‐threaded objectives with 45-mm parfocal distance
Imaging mode: fluorescence, brightfield, color brightfield, and phase contrast
Illumination: five position chamber for 4 fluorescence light cubes plus brightfield; light cubes with integrated hard coated filter set and LED light source with >50,000 hour life; broad selection of standard and specialty light cubes
Imaging methods: single color, multi-color, area scan with montage or tile-stitch, time lapse, Z-stacking, movie capture
Objective capacity: 5‐position turret
Objectives (not included): wide selection of high‐quality LWD and coverslip‐corrected objectives
Condenser: 60-mm long working distance condenser, 4 position turret with a clear aperture and 3 phase annuli
Stage: motorized X/Y scanning stage; travel range 120 mm x 80 mm with sub‐micron resolution, drop‐in inserts to receive vessel holders and lock down holders to fix sample in place during long scans
Focus mechanism: automated focus mechanism with sub‐micron resolution
LCD display: 23' high‐resolution touch screen color monitor (also fully controllable via mouse); 1920 x 1080 pixel resolution
Cameras: high-sensitivity 3.2 MP (2048 x 1536) monochrome CMOS sensor with 3.45 μm pixel resolution; high-sensitivity 3.2 MP (2048 x 1536) color CMOS sensor with 3.45 μm pixel resolution
Computer: external Dell PC with an Intel Core i7-8700 processor, 32 GB DDR4 RAM, 512 GB PCIe SSD, and NVIDIA Quadro P1000 with 4 GB discrete video graphics running Windows 10, designed to operate with touchscreen monitor and microscope
Captured images: 16‐bit RAW monochrome: TIFF, PNG; 8-bit: TIFF, PNG, JPG; movies and time‐lapse: AVI, WMV
Output ports: Computer: 1 x USB 3.1 Gen 2 Type-C; 5 x USB 3.1 Gen 1 Type-A; 4 x USB 2.0 Type-A; 1 Serial; 2 Display Ports 1.2; 1 RJ-45; 2 PS/2; 1 UAJ; 1 Line-out
Networking capability: connection through Windows/SMB network via an Ethernet cable connection
Power supply: 24 V AC adapter with country‐specific power cords
Dimensions (L x W x H): 18 x 14 x 13 inches (457 x 330 x 356 mm)
Weight: 16/35 (kg/lb)


規(guī)格

Detection Method:Chromogenic,?Fluorescent
Product Line:EVOS?
Product Size:1 system
Shipping Condition:Room Temperature


規(guī)格

Detection Method:Chromogenic,?Fluorescent
Product Line:EVOS?
Product Size:1 system
Shipping Condition:Room Temperature


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