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1
2018 - 06 - 08
2018年6月6日訊 /生物谷BIOON /——PERIOD 2 (PER2)蛋白的多點(diǎn)磷酸化是決定哺乳動(dòng)物生物鐘周期的關(guān)鍵步驟。過(guò)去的研究認(rèn)為PER2被酪蛋白激酶1(CK1)磷酸化的過(guò)程需要一種未被發(fā)現(xiàn)的蛋白激酶來(lái)啟動(dòng),而CK1是一種從藻類到人類都高度保守的生物鐘必需蛋白。這些磷酸化過(guò)程可以穩(wěn)定PER2,延緩其降解以延長(zhǎng)生物鐘周期。圖片來(lái)源:CCO public domain為了找到這個(gè)必需的蛋白質(zhì),一個(gè)由杜克-新加坡國(guó)立大學(xué)醫(yī)學(xué)院研究人員領(lǐng)導(dǎo)的國(guó)際團(tuán)隊(duì)對(duì)小鼠PER2啟動(dòng)磷酸化的過(guò)程進(jìn)行了綜合的生物化學(xué)和生物物理學(xué)分析,結(jié)果驚訝地發(fā)現(xiàn)CK1δ/ε就是他們尋找的啟動(dòng)激酶。此外,他們還發(fā)現(xiàn)CK1ε和一個(gè)最近發(fā)現(xiàn)的CK1δ2剪接變體可以比CK1δ1更有效地啟動(dòng)磷酸化。盡管過(guò)去研究顯示CK1對(duì)PER2的磷酸化對(duì)細(xì)胞環(huán)境很不敏感,但是研究人員通過(guò)使用生物節(jié)律磷酸化開關(guān)數(shù)學(xué)模型發(fā)現(xiàn)CK1羧基端尾部使得生物鐘周期對(duì)細(xì)胞信號(hào)敏感。這些研究表明CK1羧基端是生物節(jié)律的一個(gè)重要的調(diào)節(jié)因子。(生物谷Bioon.com)參考資料:Rajesh Narasimamurthy et al, CK1δ/ε protein kinase primes the PER2 circadian phosphoswitch, Proceedings of the National Academy of Sci...
2
2019 - 03 - 29
空氣污染有關(guān)眾所周知,污濁的空氣對(duì)身體有害,每年在全球范圍內(nèi)造成數(shù)百萬(wàn)人死亡。這使空氣污染成為比吸煙更厲害的殺手。然而,空氣污染對(duì)人類大腦也有害嗎?一項(xiàng)研究發(fā)現(xiàn),在英國(guó)污染最嚴(yán)重地區(qū),青少年的精神疾病問(wèn)題(包括幻覺(jué))更加常見(jiàn)。相關(guān)成果日前發(fā)表于《美國(guó)醫(yī)學(xué)會(huì)雜志—精神病學(xué)》。然而,這種關(guān)聯(lián)并非意味著吸入污濁空氣會(huì)使青少年患上精神疾病,因?yàn)榭赡苓€有其他解釋。該研究作者之一、倫敦國(guó)王學(xué)院的 Helen Fisher 表示,這項(xiàng)研究未顯示出因果關(guān)系。Fisher 和同事發(fā)現(xiàn),在 2000 名 18 歲青少年中,30% 的人報(bào)告稱其在青少年時(shí)期至少有過(guò)一次精神疾病經(jīng)歷——其他針對(duì)年輕人的研究也報(bào)告了類似數(shù)字。然而研究發(fā)現(xiàn),當(dāng)把這些青少年的住址與空氣污染情況作對(duì)照時(shí),那些生活在污染程度較高地區(qū)的青少年更有可能有精神疾病史。在氮氧化物(由柴油車產(chǎn)生的污染物)含量最高的地區(qū),每 20 名青少年中就有 12 名報(bào)告患有精神疾病;而在空氣較清潔地區(qū),降至每 20 人中有 7 人患病。目前尚不清楚空氣污染與精神疾病存在何種關(guān)聯(lián)。該團(tuán)隊(duì)提出的一種推測(cè)性機(jī)制是,污染物累積會(huì)直接影響大腦。研究表明,空氣污染與額葉皮層和嗅球的炎癥和退化有關(guān),其中嗅球是大腦中負(fù)責(zé)嗅覺(jué)的部分。而大腦炎癥已被證實(shí)與精神疾病有關(guān)。一個(gè)更簡(jiǎn)單的解釋可能是,不是污染空氣本身,而是汽車排放的噪音污染帶來(lái)了問(wèn)題。噪音污染會(huì)增加壓力、擾亂睡眠,...
3
2019 - 08 - 01
第二看臺(tái)老年性黃斑變性(AMD)、視網(wǎng)膜色素變性(RP)等視網(wǎng)膜變性疾病是目前尚無(wú)有效治療手段的兇險(xiǎn)致盲性眼病,也是公認(rèn)的 “視力殺手”。由中南大學(xué)愛(ài)爾眼科學(xué)院院長(zhǎng)唐仕波教授、愛(ài)爾眼科研究所副所長(zhǎng)陳建蘇教授帶領(lǐng)團(tuán)隊(duì),利用誘導(dǎo)多能干細(xì)胞(iPS)條件培養(yǎng)基和飛秒角膜透鏡,聯(lián)合構(gòu)建高活性視網(wǎng)膜色素上皮細(xì)胞(RPE)的研究,不但有利于對(duì)視網(wǎng)膜色素上皮細(xì)胞生理特性、藥物篩選等研究,還有利于構(gòu)建組織工程視網(wǎng)膜層及其移植。這將幫助科學(xué)家開發(fā)出應(yīng)用組織工程 RPE 細(xì)胞片治療視網(wǎng)膜變性疾病和光感受器病變的新方法。培養(yǎng)高活性的視網(wǎng)膜細(xì)胞與年齡相關(guān)的老年性黃斑變性是發(fā)達(dá)國(guó)家 50 歲以上人群視力損害和致盲的首要病因,多達(dá) 90% 的病人無(wú)法治愈。數(shù)據(jù)顯示,發(fā)達(dá)國(guó)家年齡 50 歲以上黃斑變性的發(fā)病率達(dá) 11%,目前我國(guó)的發(fā)病率接近發(fā)達(dá)國(guó)家,患病人數(shù)超過(guò) 3000 萬(wàn)人,并以每年 30 萬(wàn)人次的速度增加,成為我國(guó)現(xiàn)階段 50 歲以上年齡群體發(fā)病率最高的三大眼科疾病之一,而且女性呈現(xiàn)出比男性更高的危險(xiǎn)性。研究發(fā)現(xiàn),未來(lái)最有希望治療老年性黃斑變性的方式是視網(wǎng)膜色素上皮細(xì)胞療法、視網(wǎng)膜黃斑部分的移植。那么,要采用 RPE 療法,就需要先培養(yǎng)健康的視網(wǎng)膜細(xì)胞。陳建蘇告訴科技日?qǐng)?bào)記者,取出死亡時(shí)間在 3 小時(shí)內(nèi)捐獻(xiàn)者的帶有部分脈絡(luò)膜的視網(wǎng)膜組織,在解剖顯微鏡下可將帶有部分脈絡(luò)膜的 RPE 層從捐贈(zèng)組織中分離出來(lái),...
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產(chǎn)品名稱:

EVOS? M7000 Imaging System

上市日期: 2019-04-15
產(chǎn)品類別: EVOS

規(guī)格

Detection Method:Chromogenic,?Fluorescent
Product Line:EVOS?
Product Size:1 system
Shipping Condition:Room Temperature


  • 產(chǎn)品描述
  • 產(chǎn)品功能
  • 產(chǎn)品參數(shù)

描述

The EVOS M7000 Imaging System is a high-performance, fully automated, inverted, multi-channel fluorescence and transmitted light imaging system. It was developed to meet today’s expectations for image quality, user interface interactions, data generation speed and flexibility, and end-user value. The powerful and time-saving acquisition tools with enhanced autofocus algorithms and automated routines for microwell plate assays, time-lapse live cell imaging, area scanning in time lapse and Z-stacks in scan mode, and a superb optomechanical design enable the generation of publication-quality images and data with just a few clicks when and where needed.

The EVOS M7000 Imaging System offers these advantages:
? Outstanding image quality and versatility with a 5-position objective turret, 4-color LED fluorescence and transmitted light channels, and 3.2 MP CMOS color and B/W cameras
? Exceptional usability with fully automated X/Y scanning stage, autofocus, and acquisition routines
? High-speed image acquisition coupled with multi-position well scanning, and Z-stack and tile-stitch options lend power and flexibility to your data generation
? Fully integrated time-lapse live cell imaging using the optional EVOS Onstage Incubator for precise control of temperature, gases for normoxic or hypoxic conditions, and humidity
? Powerful image analysis capabilities for cell segmentation and quantification with the optional Celleste? Image Analysis Software

Fully automated imaging system
The EVOS M7000 system combines and integrates precision components with a unique modern design functionality that enables high-quality automated fluorescence imaging anywhere with unprecedented workflow efficiency. Full automation of the precision X/Y-stage movement; changing of the 4 LED fluorescent light cubes, 5-position objective turret, focus, and exposure; and switching of the dual camera make the EVOS M7000 system an exceptional platform for a variety of demanding imaging applications. Through the intuitive acquisition interface, you can program the EVOS M7000 system to run well-plate scanning, time lapse experiments, and tile-stitch/montage area scans in Z-stack and/or time-lapse modes in your vessel of choice. For live cell imaging over multiple hours or days, the optional EVOS Onstage Incubator, which functions as an environmental chamber on top of the microscope stage, is operated seamlessly from within the instrument interface. The EVOS M7000 system is compatible with all accessories for the predecessor EVOS FL Auto imaging system.

Versatile and highly configurable
With a 5-position objective turret and the ability to simultaneous acquire images in four fluorescence channels plus transmitted light, the optical system can be easily configured to meet your needs. Choose from our broad range of high quality coverslip-corrected and long-working-distance objectives for use with plastic vessels or glass sides. Available from 1.25X to 100X magnification in achromat, fluorite, or apochromat models, together with over twenty LED light cubes, the sample imaging options are limitless. Dual monochrome and color high-sensitivity dual CMOS cameras enable seamless imaging of both fluorescent and chromogenically stained samples. Interchangeable vessel holders accommodate most vessel types and sizes, including slides, multi-well plates, culture flasks, and Petri dishes, and afford precise control and sample alignment by the automated stage. The vessel creation wizard in the user interface enables creation of profiles for custom sample vessels.

Powerful software
The EVOS M7000 software presents users with an extensive suite of tools for acquisition, visualization, and analysis. The user interface was designed with a strong emphasis on usability, including an option to view samples in a single field mode (Field View) or in a window that covers a much larger area (Area View). By using a zoom function, the Area View size can be adjusted. A user can explore a large sample area at low magnification, define regions of interest, and then seamlessly transition to the Scan function in Automate Mode and execute an area scan at higher magnification.

The enhanced power of the EVOS M7000 system enables more demanding automated acquisition routines like area scanning in time lapse and Z-stacks in scan mode to be performed. Visualization capabilities include multi-field image viewing gallery, mosaic tiling and tile stitching options, Z-stack visualization, and a video recording and movie maker/editor for time lapse sequences. The EVOS M7000 system is fully compatible with the EVOS Onstage Incubator environmental chamber for control of temperature, gases, and humidity. With the ability generate both hypoxic and normoxic conditions, it is possible to study live cells over extended periods with highly flexible time lapse automation routines.

For users needing more powerful image analysis capabilities, images acquired on the EVOS M7000 system can be analyzed directly using the optional Celleste Image Analysis Software. Celleste software offers powerful tools for image segmentation and classification that can be applied to a range of cell analysis applications for counting and measuring intensity, area, and shape changes over time, and more.

Smart LED illumination technology
All EVOS fluorescence imaging systems utilize our proprietary LED light cubes. This light engine outputs remarkable intensity over a short light path and delivers incomparable fluorophore excitation. Each light cube contains a precisely matched set of optical components to optimize the position, evenness, and intensity of the light beam. Digitally controlled LED light sources allow adjustment of illumination levels to the sample and experimental conditions to minimize the risk of photo-toxicity and photo-bleaching in time-lapse studies. Hard-coated filters give sharper edges and significantly higher transmission efficiencies than traditional soft-coated filters.

Easy to use and reliable
The EVOS M7000 Imaging System is powerful, yet offers the simplicity of plug-and-play. Like other EVOS systems, it requires no warm-up or cool-down periods. The LED light source guarantees exceptional stability and durability, so you can turn the unit on and off whenever you need to image a sample. The environmentally safe, mercury-free LED bulbs are rated for >50,000 hours, compared to 300 hours for a typical mercury bulb and 1,500 hours for a metal halide bulb. The long lifetime and low energy consumption translate into significantly lower operating costs compared to instruments with conventional light sources. The EVOS M7000 system is powered by an external Dell PC with an Intel Core i7-8700 processor, 32 GB DDR4 RAM, 512 GB PCIe SSD, and NVIDIA Quadro P1000 with 4 GB discrete video graphics running Windows 10, designed to operate with touchscreen monitor and microscope. Whether acquiring single images or setting up automated routines, the EVOS M7000 system is remarkably easy to use and run. The 1920 x 1080 pixel resolution 23' LCD touch screen monitor enables “finger swipes” to expand or zoom in on images, and moving between microwell plate wells is done by a single touch. Operation is also also fully controllable via mouse.

The EVOS imaging systems are built from the ground up to maximize performance and optimize workflow. You will be astonished at how easy it is to operate and amazed at how extraordinary your images look on-screen.

Explore the entire EVOS line of imaging systems, accessories, and offers ?

System and hardware specifications
Optics: infinity‐corrected optical system; RMS‐threaded objectives with 45-mm parfocal distance
Imaging mode: fluorescence, brightfield, color brightfield, and phase contrast
Illumination: five position chamber for 4 fluorescence light cubes plus brightfield; light cubes with integrated hard coated filter set and LED light source with >50,000 hour life; broad selection of standard and specialty light cubes
Imaging methods: single color, multi-color, area scan with montage or tile-stitch, time lapse, Z-stacking, movie capture
Objective capacity: 5‐position turret
Objectives (not included): wide selection of high‐quality LWD and coverslip‐corrected objectives
Condenser: 60-mm long working distance condenser, 4 position turret with a clear aperture and 3 phase annuli
Stage: motorized X/Y scanning stage; travel range 120 mm x 80 mm with sub‐micron resolution, drop‐in inserts to receive vessel holders and lock down holders to fix sample in place during long scans
Focus mechanism: automated focus mechanism with sub‐micron resolution
LCD display: 23' high‐resolution touch screen color monitor (also fully controllable via mouse); 1920 x 1080 pixel resolution
Cameras: high-sensitivity 3.2 MP (2048 x 1536) monochrome CMOS sensor with 3.45 μm pixel resolution; high-sensitivity 3.2 MP (2048 x 1536) color CMOS sensor with 3.45 μm pixel resolution
Computer: external Dell PC with an Intel Core i7-8700 processor, 32 GB DDR4 RAM, 512 GB PCIe SSD, and NVIDIA Quadro P1000 with 4 GB discrete video graphics running Windows 10, designed to operate with touchscreen monitor and microscope
Captured images: 16‐bit RAW monochrome: TIFF, PNG; 8-bit: TIFF, PNG, JPG; movies and time‐lapse: AVI, WMV
Output ports: Computer: 1 x USB 3.1 Gen 2 Type-C; 5 x USB 3.1 Gen 1 Type-A; 4 x USB 2.0 Type-A; 1 Serial; 2 Display Ports 1.2; 1 RJ-45; 2 PS/2; 1 UAJ; 1 Line-out
Networking capability: connection through Windows/SMB network via an Ethernet cable connection
Power supply: 24 V AC adapter with country‐specific power cords
Dimensions (L x W x H): 18 x 14 x 13 inches (457 x 330 x 356 mm)
Weight: 16/35 (kg/lb)


規(guī)格

Detection Method:Chromogenic,?Fluorescent
Product Line:EVOS?
Product Size:1 system
Shipping Condition:Room Temperature


規(guī)格

Detection Method:Chromogenic,?Fluorescent
Product Line:EVOS?
Product Size:1 system
Shipping Condition:Room Temperature


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