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1
2018 - 06 - 08
2018年6月6日訊 /生物谷BIOON /——PERIOD 2 (PER2)蛋白的多點(diǎn)磷酸化是決定哺乳動(dòng)物生物鐘周期的關(guān)鍵步驟。過(guò)去的研究認(rèn)為PER2被酪蛋白激酶1(CK1)磷酸化的過(guò)程需要一種未被發(fā)現(xiàn)的蛋白激酶來(lái)啟動(dòng),而CK1是一種從藻類(lèi)到人類(lèi)都高度保守的生物鐘必需蛋白。這些磷酸化過(guò)程可以穩(wěn)定PER2,延緩其降解以延長(zhǎng)生物鐘周期。圖片來(lái)源:CCO public domain為了找到這個(gè)必需的蛋白質(zhì),一個(gè)由杜克-新加坡國(guó)立大學(xué)醫(yī)學(xué)院研究人員領(lǐng)導(dǎo)的國(guó)際團(tuán)隊(duì)對(duì)小鼠PER2啟動(dòng)磷酸化的過(guò)程進(jìn)行了綜合的生物化學(xué)和生物物理學(xué)分析,結(jié)果驚訝地發(fā)現(xiàn)CK1δ/ε就是他們尋找的啟動(dòng)激酶。此外,他們還發(fā)現(xiàn)CK1ε和一個(gè)最近發(fā)現(xiàn)的CK1δ2剪接變體可以比CK1δ1更有效地啟動(dòng)磷酸化。盡管過(guò)去研究顯示CK1對(duì)PER2的磷酸化對(duì)細(xì)胞環(huán)境很不敏感,但是研究人員通過(guò)使用生物節(jié)律磷酸化開(kāi)關(guān)數(shù)學(xué)模型發(fā)現(xiàn)CK1羧基端尾部使得生物鐘周期對(duì)細(xì)胞信號(hào)敏感。這些研究表明CK1羧基端是生物節(jié)律的一個(gè)重要的調(diào)節(jié)因子。(生物谷Bioon.com)參考資料:Rajesh Narasimamurthy et al, CK1δ/ε protein kinase primes the PER2 circadian phosphoswitch, Proceedings of the National Academy of Sci...
2
2019 - 03 - 29
空氣污染有關(guān)眾所周知,污濁的空氣對(duì)身體有害,每年在全球范圍內(nèi)造成數(shù)百萬(wàn)人死亡。這使空氣污染成為比吸煙更厲害的殺手。然而,空氣污染對(duì)人類(lèi)大腦也有害嗎?一項(xiàng)研究發(fā)現(xiàn),在英國(guó)污染最嚴(yán)重地區(qū),青少年的精神疾病問(wèn)題(包括幻覺(jué))更加常見(jiàn)。相關(guān)成果日前發(fā)表于《美國(guó)醫(yī)學(xué)會(huì)雜志—精神病學(xué)》。然而,這種關(guān)聯(lián)并非意味著吸入污濁空氣會(huì)使青少年患上精神疾病,因?yàn)榭赡苓€有其他解釋。該研究作者之一、倫敦國(guó)王學(xué)院的 Helen Fisher 表示,這項(xiàng)研究未顯示出因果關(guān)系。Fisher 和同事發(fā)現(xiàn),在 2000 名 18 歲青少年中,30% 的人報(bào)告稱(chēng)其在青少年時(shí)期至少有過(guò)一次精神疾病經(jīng)歷——其他針對(duì)年輕人的研究也報(bào)告了類(lèi)似數(shù)字。然而研究發(fā)現(xiàn),當(dāng)把這些青少年的住址與空氣污染情況作對(duì)照時(shí),那些生活在污染程度較高地區(qū)的青少年更有可能有精神疾病史。在氮氧化物(由柴油車(chē)產(chǎn)生的污染物)含量最高的地區(qū),每 20 名青少年中就有 12 名報(bào)告患有精神疾??;而在空氣較清潔地區(qū),降至每 20 人中有 7 人患病。目前尚不清楚空氣污染與精神疾病存在何種關(guān)聯(lián)。該團(tuán)隊(duì)提出的一種推測(cè)性機(jī)制是,污染物累積會(huì)直接影響大腦。研究表明,空氣污染與額葉皮層和嗅球的炎癥和退化有關(guān),其中嗅球是大腦中負(fù)責(zé)嗅覺(jué)的部分。而大腦炎癥已被證實(shí)與精神疾病有關(guān)。一個(gè)更簡(jiǎn)單的解釋可能是,不是污染空氣本身,而是汽車(chē)排放的噪音污染帶來(lái)了問(wèn)題。噪音污染會(huì)增加壓力、擾亂睡眠,...
3
2019 - 08 - 01
第二看臺(tái)老年性黃斑變性(AMD)、視網(wǎng)膜色素變性(RP)等視網(wǎng)膜變性疾病是目前尚無(wú)有效治療手段的兇險(xiǎn)致盲性眼病,也是公認(rèn)的 “視力殺手”。由中南大學(xué)愛(ài)爾眼科學(xué)院院長(zhǎng)唐仕波教授、愛(ài)爾眼科研究所副所長(zhǎng)陳建蘇教授帶領(lǐng)團(tuán)隊(duì),利用誘導(dǎo)多能干細(xì)胞(iPS)條件培養(yǎng)基和飛秒角膜透鏡,聯(lián)合構(gòu)建高活性視網(wǎng)膜色素上皮細(xì)胞(RPE)的研究,不但有利于對(duì)視網(wǎng)膜色素上皮細(xì)胞生理特性、藥物篩選等研究,還有利于構(gòu)建組織工程視網(wǎng)膜層及其移植。這將幫助科學(xué)家開(kāi)發(fā)出應(yīng)用組織工程 RPE 細(xì)胞片治療視網(wǎng)膜變性疾病和光感受器病變的新方法。培養(yǎng)高活性的視網(wǎng)膜細(xì)胞與年齡相關(guān)的老年性黃斑變性是發(fā)達(dá)國(guó)家 50 歲以上人群視力損害和致盲的首要病因,多達(dá) 90% 的病人無(wú)法治愈。數(shù)據(jù)顯示,發(fā)達(dá)國(guó)家年齡 50 歲以上黃斑變性的發(fā)病率達(dá) 11%,目前我國(guó)的發(fā)病率接近發(fā)達(dá)國(guó)家,患病人數(shù)超過(guò) 3000 萬(wàn)人,并以每年 30 萬(wàn)人次的速度增加,成為我國(guó)現(xiàn)階段 50 歲以上年齡群體發(fā)病率最高的三大眼科疾病之一,而且女性呈現(xiàn)出比男性更高的危險(xiǎn)性。研究發(fā)現(xiàn),未來(lái)最有希望治療老年性黃斑變性的方式是視網(wǎng)膜色素上皮細(xì)胞療法、視網(wǎng)膜黃斑部分的移植。那么,要采用 RPE 療法,就需要先培養(yǎng)健康的視網(wǎng)膜細(xì)胞。陳建蘇告訴科技日?qǐng)?bào)記者,取出死亡時(shí)間在 3 小時(shí)內(nèi)捐獻(xiàn)者的帶有部分脈絡(luò)膜的視網(wǎng)膜組織,在解剖顯微鏡下可將帶有部分脈絡(luò)膜的 RPE 層從捐贈(zèng)組織中分離出來(lái),...
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產(chǎn)品名稱(chēng):

EVOS? 50X Oil Objective, achromat, coverslip-corrected

上市日期: 2019-04-15
產(chǎn)品類(lèi)別: EVOS

規(guī)格

For Use With (Equipment):EVOS? FL Auto Imaging System,?EVOS? FL Color Imaging System,?EVOS? FL Imaging System
Lens Type:Plan Achromat
Magnification:50X
Product Line:EVOS?
Product Size:1 each
Quantity:1 each
Type:Objective Lens


  • 產(chǎn)品描述
  • 產(chǎn)品功能
  • 產(chǎn)品參數(shù)

描述

This achromat objective is ideal for general applications. This is a coverslip-corrected objective that is optimized for imaging through #1.5 coverslips. All EVOS? objectives offer outstanding optical performance from visible light to near infrared light. The extensive choice of objectives satisfies needs across the spectrum of magnifications and optical specifications.

Additional characteristics of this EVOS? objective:

? Magnification: 50X
? Numerical Aperture: 0.95
? Working Distance: 0.19
? Immersion: Oil

Image Quality
Microscope objectives may be the most important components of an optical microscope because they are responsible for primary image formation. Image quality is crucial to experimental success and a requirement for publication; EVOS? objectives afford that quality across the visible spectrum to near infrared light. This performance results from years of lens manufacture perfection. EVOS? objectives have the same or better numerical apertures as any other manufacturer's in the same class, and the broad selection means you have choices for your imaging requirements.

Objective Classes

Achromat objectives are perfect for general applications, with standard correction of color and focus.

Fluorite objectives deliver excellent resolution and are made with higher numerical apertures than achromat objectives, resulting in brighter fluorescence signal and higher contrast imaging. The higher optical quality greatly reduces optical aberrations, and corrections for color and focus are at higher levels than achromat objectives. Fluorite objectives are ideally suited for fluorescence and demanding transmitted light applications, where the higher contrast make them ideally suited for color imaging.

Apochromat objectives are manufactured to the highest levels of resolution, fluorescence brightness, and contrast; chromatic aberrations are almost eliminated. They are recommended for the most demanding applications, particularly at magnifications of 60x and above. Apochromatic objectives are the best choice for the capture of color images in white light.

Brightfield Contrast versus Phase Contrast Objectives
Brightfield is the most basic form of light microscopy and is accomplished by sample absorption of light. A higher density area in a sample will absorb more light, thus increasing contrast in those areas.

Phase contrast objectives are most useful for hard to see, translucent specimens. This method of contrast is accomplished by converting phase shifts, caused by light passing through a translucent specimen, into brightness changes (i.e., contrast).

Long Working Distance versus Coverslip-Corrected Objectives
Long working distance (LWD) objectives are optimized for use through vessels with a nominal wall thickness of 0.9-1.5 mm. This includes vessels commonly used in cell culture and cell-based assays, such as slides, cell culture dishes and flasks, microtiter well plates, etc. Coverslip-corrected objectives are optimized for use through #1.5 coverslips (thickness approximately 0.17 mm). These objectives have a higher magnification/NA ratio and provide higher resolution compared to LWD objectives.


規(guī)格

For Use With (Equipment):EVOS? FL Auto Imaging System,?EVOS? FL Color Imaging System,?EVOS? FL Imaging System
Lens Type:Plan Achromat
Magnification:50X
Product Line:EVOS?
Product Size:1 each
Quantity:1 each
Type:Objective Lens


規(guī)格

For Use With (Equipment):EVOS? FL Auto Imaging System,?EVOS? FL Color Imaging System,?EVOS? FL Imaging System
Lens Type:Plan Achromat
Magnification:50X
Product Line:EVOS?
Product Size:1 each
Quantity:1 each
Type:Objective Lens


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