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J Appl Physiol：中年時(shí)期的有氧運(yùn)動或能預(yù)防多種與年齡相關(guān)的慢性疾病

2021 - 11 - 06

來自美國和日本的科學(xué)家們通過研究發(fā)現(xiàn)，由于進(jìn)行了有規(guī)律的有氧運(yùn)動，相比年輕成年人而言，中年的耐力運(yùn)動員還會顯示出相當(dāng)水平的上述因素。本文研究結(jié)果提供了強(qiáng)有力的跡象表明，血壓的控制和血管彈性程度的改善或有助于更好地改善中年人群大腦血流的調(diào)節(jié)。2021年12月19日訊 /生物谷BIOON/ --中年有氧運(yùn)動或能顯著影響年齡相關(guān)的大腦和心血管調(diào)節(jié)的變化，中年耐力運(yùn)動員要比相同年齡組的久坐成年人有著更好的血壓控制和更高的動脈彈性（一種心血管疾病風(fēng)險(xiǎn)的無創(chuàng)測量）。近日，一篇發(fā)表在國際雜志Journal of applied Physiology上題為“Midlife aerobic exercise and dynamic cerebral autoregulation： associations with baroreflex sensitivity and central arterial stiffness”的研究報(bào)告中，來自美國和日本的科學(xué)家們通過研究發(fā)現(xiàn)，由于進(jìn)行了有規(guī)律的有氧運(yùn)動，相比年輕成年人而言，中年的耐力運(yùn)動員還會顯示出相當(dāng)水平的上述因素。本文研究結(jié)果提供了強(qiáng)有力的跡象表明，血壓的控制和血管彈性程度的改善或有助于更好地改善中年人群大腦血流的調(diào)節(jié)。圖片來源：Pixabay/CC0 Public Domain中年機(jī)體動脈的僵硬程度與晚年中風(fēng)和癡呆癥風(fēng)險(xiǎn)增加有關(guān)，同時(shí)還會增加機(jī)...

Nature：挑戰(zhàn)常規(guī)！揭示一些乳腺癌和卵巢癌對PARP抑制劑產(chǎn)生耐藥性的新機(jī)制

2018 - 07 - 20

一種非常復(fù)雜的治療一些乳腺癌和卵巢癌的方法就是使用一類叫做PARP抑制劑的藥物。PARP抑制劑旨在利用讓發(fā)生某些突變的腫瘤特別致命的缺陷。然而，這種靶向癌癥治療方法有時(shí)會失敗，科學(xué)家們迫切地想要知道其中的原因。如今，在一項(xiàng)新的研究中，美國洛克菲勒大學(xué)的Titia de Lange教授及其團(tuán)隊(duì)對這種耐藥性機(jī)制提供了新的認(rèn)識，并且為抵抗這種耐藥性提供了新的希望。他們發(fā)現(xiàn)了由基因BRCA1發(fā)生的錯(cuò)誤引發(fā)的一些癌癥逃避旨在殺死它們的定制藥物的分子機(jī)制。這一發(fā)現(xiàn)也挑戰(zhàn)了之前針對這些PARP抑制劑成功地或未能給患者帶來益處的機(jī)制作出的猜測。相關(guān)研究結(jié)果于2018年7月18日在線發(fā)表在Nature期刊上，論文標(biāo)題為“53BP1–RIF1–shieldin counteracts DSB resection through CST- and Polα-dependent fill-in”。圖片來自Laboratory of Cell Biology and Genetics at The Rockefeller University。他們的發(fā)現(xiàn)有助于解釋為什么某些癌癥會對PARP抑制劑作出反應(yīng)，而其他癌癥卻沒有---這種認(rèn)識最終可能有助于改善對患者的治療。缺陷和機(jī)會專家們預(yù)測今年將有大約288000例乳腺癌和卵巢癌新確診病例。這些癌癥的很大一部分是由人類基因組中的兩個(gè)最臭名昭著的基因--- ...

Sci Rep：抑制蛋白質(zhì)磷酸化制促進(jìn)損傷后的視神經(jīng)再生

2019 - 05 - 23

2019年5月22日訊 /生物谷BIOON/ --早稻田大學(xué)Toshio Ohshima教授的一項(xiàng)新研究發(fā)現(xiàn)，抑制塌陷反應(yīng)介質(zhì)蛋白2（CRMP2）（一種微管結(jié)合蛋白）的磷酸化可以抑制神經(jīng)纖維的退化，促進(jìn)視神經(jīng)損傷后的再生。最近在《Scientific Reports》雜志上發(fā)表的這項(xiàng)研究結(jié)果可以為視神經(jīng)病變患者開發(fā)新型治療方法。青光眼患者視野中會出現(xiàn)盲點(diǎn)，并且當(dāng)視神經(jīng)惡化時(shí)可能導(dǎo)致失明。神經(jīng)纖維的這種惡化和功能喪失也發(fā)生在創(chuàng)傷性神經(jīng)損傷和神經(jīng)系統(tǒng)疾病，例如阿爾茨海默病和ALS中。目前，由于軸突再生受到抑制因子的限制，因此不存在在損傷或變性后完全修復(fù)視網(wǎng)膜，脊髓和中樞神經(jīng)系統(tǒng)的其他部分的方法。（圖片來源：Www.pixabay.com）在過去的研究中，已經(jīng)發(fā)現(xiàn)了抑制軸突再生的潛在機(jī)制，并且認(rèn)為解決這些機(jī)制可以使科學(xué)家們在開發(fā)新的中樞神經(jīng)系統(tǒng)損傷治療方法方面更進(jìn)一步。CRMP2蛋白質(zhì)分子起到穩(wěn)定微管的作用，微管在神經(jīng)元細(xì)胞水平為中樞神經(jīng)系統(tǒng)提供結(jié)構(gòu)支持，并通過與微管蛋白二聚體結(jié)合促進(jìn)聚合。然而，這些功能通過磷酸化（一種調(diào)節(jié)神經(jīng)元蛋白的機(jī)制）被各種激酶阻止?！霸谖覀冎暗难芯恐?，我們所做的是開發(fā)CRMP2敲入小鼠并從基因上抑制其CRMP2磷酸化，”O(jiān)hshima教授解釋說。 “結(jié)果，CRMP2敲入小鼠在脊髓損傷后表現(xiàn)出軸突再生的促進(jìn)。由此，我們假設(shè)在視神經(jīng)損傷后也可以觀察到相同的現(xiàn)象。...

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產(chǎn)品名稱： EVOS? Vessel Holder, two 25-cm T-flasks

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時(shí)間： 2019 - 04 - 15

描述EVOS® vessel holders allow a perfect fit of your microscope slide, cell culture flask or dish, or micro-well plate to the stage of the EVOS® imaging systems for increased precision in sample alignment. This particular vessel holder accommodates two 25 cm T-flasks. It is just one of many easy-to-change vessel holders and stage plates available for this instrument platform. With a snug and secure fit, yet readily switched, these accessories make imaging samples in a range of vessel ...

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產(chǎn)品名稱： EVOS? Vessel Holder, one 100-mm Petri dish

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時(shí)間： 2019 - 04 - 15

描述EVOS® vessel holders allow a perfect fit of your microscope slide, cell culture flask or dish, or micro-well plate to the stage of the EVOS® imaging systems for increased precision in sample alignment. This particular vessel holder accommodates one 100 mm Petri dish. It is just one of many easy-to-change vessel holders and stage plates available for this instrument platform. With a snug and secure fit, yet readily switched, these accessories make imaging samples in a range of vess...

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產(chǎn)品名稱： EVOS? Vessel Holder, two 60-mm Petri dishes

型號：

時(shí)間： 2019 - 04 - 15

描述EVOS® vessel holders allow a perfect fit of your microscope slide, cell culture flask or dish, or micro-well plate to the stage of the EVOS® imaging systems for increased precision in sample alignment. This particular vessel holder accommodates two 60 mm Petri dishes. It is just one of many easy-to-change vessel holders and stage plates available for this instrument platform. With a snug and secure fit, yet readily switched, these accessories make imaging samples in a range of ves...

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產(chǎn)品名稱： EVOS? Vessel Holder, four 35-mm Petri dishes

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時(shí)間： 2019 - 04 - 12

描述EVOS® vessel holders allow a perfect fit of your microscope slide, cell culture flask or dish, or micro-well plate to the stage of the EVOS® imaging systems for increased precision in sample alignment. This particular vessel holder accommodates four 35 mm Petri dishes. It is just one of many easy-to-change vessel holders and stage plates available for this instrument platform. With a snug and secure fit, yet readily switched, these accessories make imaging samples in a range of ve...

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產(chǎn)品名稱： EVOS? Vessel Holder, two 25 x 75 mm slides

型號：

時(shí)間： 2019 - 04 - 12

描述EVOS® vessel holders allow a perfect fit of your microscope slide, cell culture flask or dish, or micro-well plate to the stage of the EVOS® imaging systems for increased precision in sample alignment. This particular vessel holder accommodates two 25 x 75 mm slides. It is just one of many easy-to-change vessel holders and stage plates available for this instrument platform. With a snug and secure fit, yet readily switched, these accessories make imaging samples in a range of vess...

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產(chǎn)品名稱： EVOS? 4X Objective, fluorite, LWD, phase-contrast

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時(shí)間： 2019 - 04 - 12

描述This fluorite objective is ideal for fluorescence and demanding transmitted-light applications. This is a long working distance (LWD) objective that is optimized for the imaging of slides, cell culture dishes and flasks, and microtiter plates. This is also a phase-contrast objective, making it useful for hard-to-see, translucent speciments. All EVOS® objectives offer outstanding optical performance from visible light to near infrared light. The extensive choice of objectives satisfies nee...

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產(chǎn)品名稱： EVOS? Light Cube, Cy?5

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時(shí)間： 2019 - 04 - 12

描述All EVOS® fluorescence imaging systems and the Countess® II FL Automated Cell Counter contain our unique, proprietary LED light cubes. This world-leading light engine outputs remarkable intensity over a short light path that delivers superior fluorophore excitation. Each cube contains an LED, condensing optics, and hard-coated filters. EVOS® light cubes are user-changeable and automatically recognized by the system. The Cy®5 light cube is ideal for use with Alexa Fluor&...

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產(chǎn)品名稱： EVOS? Light Cube, RFP

型號：

時(shí)間： 2019 - 04 - 12

描述All EVOS® fluorescence imaging systems and the Countess® II FL Automated Cell Counter contain our unique, proprietary LED light cubes. This world-leading light engine outputs remarkable intensity over a short light path that delivers superior fluorophore excitation. Each cube contains an LED, condensing optics, and hard-coated filters. EVOS® light cubes are user-changeable and automatically recognized by the system. The RFP light cube is ideal for use with Alexa Fluor® ...

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產(chǎn)品名稱： EVOS? Light Cube, GFP

型號：

時(shí)間： 2019 - 04 - 12

描述All EVOS® fluorescence imaging systems and the Countess® II FL Automated Cell Counter contain our unique, proprietary LED light cubes. This world-leading light engine outputs remarkable intensity over a short light path that delivers superior fluorophore excitation. Each cube contains an LED, condensing optics, and hard-coated filters. EVOS® light cubes are user-changeable and automatically recognized by the system. The GFP light cube is ideal for use with Alexa Fluor® ...

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產(chǎn)品名稱： EVOS? Light Cube, DAPI

型號：

時(shí)間： 2019 - 04 - 12

描述All EVOS® fluorescence imaging systems and the Countess® II FL Automated Cell Counter contain our unique, proprietary LED light cubes. This world-leading light engine outputs remarkable intensity over a short light path that delivers superior fluorophore excitation. Each cube contains an LED, condensing optics, and hard-coated filters. EVOS® light cubes are user-changeable and automatically recognized by the system. The DAPI light cube is ideal for use with Acridine, Alexa F...

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產(chǎn)品名稱： EVOS? Power Cord, Type I (Australia)

型號：

時(shí)間： 2019 - 04 - 12

描述This power cord is for use with EVOS® XL, FL , FL Color, and FL Auto systems in countries with Type I power plugs. The Type I electrical plug is mainly used in Australia and New Zealand, but is also used in China and parts of Asia, South America, and Africa.

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產(chǎn)品名稱： EVOS? 20X Objective, achromat, LWD, phase-contrast

型號：

時(shí)間： 2019 - 04 - 11

描述This achromat objective is ideal for general applications. This is a long working distance (LWD) objective that is optimized for the imaging of slides, cell culture dishes and flasks, and microtiter plates. This is also a phase-contrast objective, making it useful for hard-to-see, translucent speciments. All EVOS® objectives offer outstanding optical performance from visible light to near infrared light. The extensive choice of objectives satisfies needs across the spectrum of magnificati...

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