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1
2018 - 07 - 05
doi.org/10.1038/s41586-018-0162-7基于20年的深入研究，得克薩斯大學(xué)西南醫(yī)學(xué)中心（UT Southwestern）自噬研究中心的主任Beth Levine和團隊已經(jīng)明確：細(xì)胞自噬可以延長壽命、改善健康。他們以小鼠為模型發(fā)現(xiàn)，自噬水平提高的小鼠壽命更長、更健康?！熬唧w來說，它們的壽命延長了約10%，且不太可能發(fā)生與年齡相關(guān)的自發(fā)性癌癥、心臟病等疾病?！盉eth Levine表示道。細(xì)胞自噬自噬是一種保護機制。當(dāng)細(xì)胞內(nèi)出現(xiàn)衰老的蛋白質(zhì)、損壞的細(xì)胞器等廢棄物時，自噬囊泡會將它們包裹并送至溶酶體中進行降解并得以循環(huán)利用，從而確保細(xì)胞本身的代謝需求和某些細(xì)胞器的更新。細(xì)胞自噬過程（圖片來源：華威大學(xué)）20年前，Beth Levine和同事發(fā)現(xiàn)了自噬生物學(xué)過程中的一個關(guān)鍵基因beclin 1。他們還發(fā)現(xiàn)，自噬對于健康而言必不可少，例如預(yù)防神經(jīng)衰退性疾病、對抗癌癥和感染。2003年，Beth Levine團隊證實，自噬關(guān)聯(lián)的基因機制對于長壽突變線蟲（long-lived mutant roundworms）的壽命延長至關(guān)重要?！皬哪且院?，關(guān)于‘自噬是延長壽命的關(guān)鍵機制’的觀點尤為火熱?！?Beth Levine解釋道，“隨著年齡增長，細(xì)胞的自噬能力會下降，這可能會導(dǎo)致衰老?！弊允裳娱L壽命然而，一個關(guān)鍵問題仍然沒有得到解答：增強自噬水平是否有益于哺乳動物的健康？換句...
2
2019 - 05 - 06
來源： 中國科學(xué)報年初，一部電視劇《都挺好》火遍全國，大結(jié)局時劇中一直讓人恨得牙癢癢的 “作爹” 蘇大強，因患上了阿爾茨海默氏癥（AD，俗稱老年癡呆癥）而成功“洗白”，惹出了不少人的眼淚。阿爾茨海默氏癥離我們并不遙遠(yuǎn)，由它引發(fā)的故事也是常有耳聞，大多伴隨著無奈與辛酸。隨著全球老齡化進程的加快，愈來愈多的阿爾茨海默氏癥患者將給家屬及社會帶來沉重的負(fù)擔(dān)。根據(jù)國際阿爾茨海默氏病協(xié)會的統(tǒng)計數(shù)據(jù)，2018 年全世界有 5000 萬老人患有癡呆，每 3 秒鐘，就有 1 位患者產(chǎn)生；中國是阿爾茨海默氏病的重災(zāi)區(qū)，估計有 1000 萬患者。關(guān)于阿爾茨海默氏癥發(fā)病機制和治療方法的研究一直都是科研界關(guān)注的重點之一。近日，中國科學(xué)院昆明動物研究所姚永剛課題組在阿爾茨海默氏癥的治療研究上取得重要進展，該研究闡明了核受體過氧化物酶體α激動劑吉非羅齊和匹立尼酸的抗阿爾茨海默氏癥分子機制。相關(guān)論文在線發(fā)表于《自噬》（Autophagy）雜志上。誘導(dǎo)自噬，清除 Aβ作為發(fā)生在老年前期與老年期的一種常見的神經(jīng)退行性腦病，阿爾茨海默氏癥是最常見的老年癡呆類型，其發(fā)病率隨著年齡增長而顯著增加。其臨床表現(xiàn)為病人漸進性記憶喪失、認(rèn)知能力下降并伴有焦慮等其他精神相關(guān)癥狀。對于阿爾茨海默氏癥的發(fā)病機制，現(xiàn)有很多學(xué)說，其中影響最廣泛的有β- 淀粉樣蛋白（β-amyloid，Aβ）瀑布理論，認(rèn)為 Aβ的生成與清除失衡是導(dǎo)致神經(jīng)元變...
3
2019 - 09 - 05
2016年《消失的微生物》一書問世，腸道微生態(tài)研究走入大眾視野，目前全球范圍內(nèi)針對微生物與肥胖、哮喘、過敏、糖尿病、腫瘤、精神類疾病的研究正逐步開展。一、腸道微生物概況人體是由自身細(xì)胞及共生的大量微生物細(xì)胞所共同組成的復(fù)雜共生生命體。目前研究認(rèn)為人體腸道內(nèi)聚集的微生物數(shù)目可達1012~1014個，是人體自身細(xì)胞數(shù)目的10倍，微生物包含的基因數(shù)目超過987萬個，人類自身基因數(shù)只有2萬個左右，是人體自身基因數(shù)目的幾百倍，這些后天獲得的共生菌群及其所攜帶的遺傳及分子信息即可稱為微生物組。（一）人體腸道微生物是如何建立的？有研究表明，人體在出生成長過程中，主要在兩個重要的環(huán)節(jié)、以兩種不同的方式實現(xiàn)對腸道菌群的塑造。第一個環(huán)節(jié)是在分娩過程，嬰兒會從母親產(chǎn)道獲得健康的腸道菌群，剖腹產(chǎn)和孕期抗生素則會改變正常嬰兒菌群的建立。另一個環(huán)節(jié)則是出生后的哺乳及斷奶后的膳食干預(yù)。在女性乳腺中存在著乳酸菌等系列微生物，這些微生物在哺乳過程中進入并定植于嬰兒腸道。隨著哺乳期的結(jié)束，日趨豐富的膳食外源營養(yǎng)物質(zhì)則長期調(diào)節(jié)著人體腸道微生物中的的變化。（二）腸道微生物對人體健康有何影響？腸道菌群與人體互利共生，依靠人體沒有消化的食物殘渣和腸道分泌的黏液和脫落的死細(xì)胞作為營養(yǎng)來維持很高的種群水平?；钴S生長的腸道菌群會產(chǎn)生大量的活性物質(zhì)，同時包括短鏈脂肪酸、維生素和抗氧化等有益健康的產(chǎn)物，以及神經(jīng)毒素、致癌物質(zhì)和免疫毒素...
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時間： 2019 - 04 - 22
描述The LIVE/DEAD? Fixable Green Dead Cell Stain Kit is used to determine the viability of cells prior to the fixation and permeabilization required for intracellular antibody staining or prior to elimination of biohazardous materials using formaldehyde fixation. This kit has been optimized and validated for use with a blue laser flow cytometer.? Stable—dyes are freeze dried in separate vials to maintain stability? Robust—staining pattern is the same before and after fixation? Bright signal—allows...
型號：
時間： 2019 - 04 - 18
描述This product detects the externalization of phosphatidylserine in apoptotic cells using recombinant annexin V conjugated to green-fluorescent FITC dye and dead cells using propidium iodide (PI). Propidium iodide stains necrotic cells with red fluorescence. After treatment with both probes, apoptotic cells show green fluorescence, dead cells show red and green fluorescence, and live cells show little or no fluorescence.
型號：
時間： 2019 - 04 - 18
描述SYTOX® Green nucleic acid stain is an excellent green-fluorescent nuclear and chromosome counterstain that is impermeant to live cells, making it a useful indicator of dead cells within a population.?  Impermeant to live cells?  Excitation/Emission: 504/523 nm?  Use with 488 Argon-ion laser?  Works with mammalian cells and both Gram-positive and Gram-negative bacteriaSimple Viability Determination SYTOX® Green allows quick determination of cell viability when usin...
型號：
時間： 2019 - 04 - 18
描述Premo? FUCCI Cell Cycle Sensor is a fluorescent, two-color sensor of cell cycle progression and division in live cells. It allows accurate and sensitive cell cycle analysis of individual cells or a population of cells by fluorescence microscopy, flow cytometry, or high-content imaging.At 2 x 200 µL, this is a smaller pack size version (1/5 volume) of the popular full-size product and perfect for testing its performance in your system.The Premo? FUCCI Cell Cycle Sensor is delivered by high...
型號：
時間： 2019 - 04 - 18
描述CountBright? absolute counting beads are a calibrated suspension of microspheres that are brightly fluorescent across a wide range of excitation and emission wavelengths (UV to 635 nm excitation and 385-800 nm emission). CountBright? absolute counting beads are mixed with the cell sample and assayed via flow cytometry. By comparing the ratio of bead events to cell events, absolute numbers of cells in the sample can be calculated. Because CountBright? beads are mixed in the test sample, absolut...
型號：
時間： 2019 - 04 - 17
描述CellTrace? CFSE Cell Proliferation Kit is used for in vitro and in vivo labeling of cells to trace multiple generations using dye dilution by flow cytometry.? Superior performance—bright, single-peak staining enables visualization of multiple generations? Long-term signal stability—well-retained in cells for several days post stain? Non-toxic—staining does not adversely effect cell health? Simple, robust staining protocolView a selection guide for all CellTrace? Cell Proliferation Kits fo...
型號：
時間： 2019 - 04 - 17
描述CellTrace? CFSE 細(xì)胞增殖試劑盒 (CellTrace? CFSE Cell Proliferation Kit) 以方便的一次性瓶裝形式提供用途廣泛，穩(wěn)定性高的細(xì)胞示蹤劑。 羧基熒光素二醋酸鹽琥珀酰亞胺酯，常稱為 CFSE，可被動擴散進入細(xì)胞。 這種試劑沒有顏色和熒光，直至細(xì)胞內(nèi)的酯酶去除其醋酸鹽基團，產(chǎn)生能發(fā)出明亮熒光的羧基熒光素琥珀酰亞胺酯。 琥珀酰亞胺酯與細(xì)胞內(nèi)氨基反應(yīng)，形成穩(wěn)定且能用醛固定劑固定的熒光偶聯(lián)物。 此試劑盒包含十份一次性瓶裝的 CFSE，因此進行小規(guī)模實驗時無需制備過量的易變質(zhì) CFSE 儲存液。 此試劑盒還包括高質(zhì)量的 DMSO（二甲基亞砜）和詳細(xì)的實驗方案。For Research Use Only. Not for use in diagnostic procedures.圖表Suppressive capacity of isolated Treg cells.Suppressive capacity of isolated Treg cells. (A) CD4+ CD25–cells were stained with Ca...
型號：
時間： 2019 - 04 - 17
描述The Click-iT® EdU Pacific Blue? Flow Cytometry Assay Kit provides a simplified, more robust assay for analyzing DNA replication in proliferating cells as compared to traditional BrdU methods. Newly synthesized DNA is analyzed using the 405 nm laser of the flow cytometer.? Accurate—superior results compared to BrdU assays? Fast—results in as little as 90 minutes? Economical—more assays per kitView selection guide for all Click-iT? EdU and Click-iT? Plus EdU assays for flow c...
型號：
時間： 2019 - 04 - 17
描述The 2018 Attune NxT Acoustic Focusing Cytometer has expanded functionalities to drive your research forward. Designed and developed to remove common barriers associated with flow cytometry, the evolutionary capabilities of the Attune NxT flow cytometer offer adaptable optical configuration options so you can get the most out of your multicolor analysis.? Free Attune NxT software with researcher-inspired upgrades? New green laser option for expanded utility and fluorochrome options? Simple push...
型號：
時間： 2019 - 04 - 17
描述The 2018 Attune NxT Acoustic Focusing Cytometer has expanded functionalities to drive your research forward. Designed and developed to remove common barriers associated with flow cytometry, the evolutionary capabilities of the Attune NxT flow cytometer offer adaptable optical configuration options so you can get the most out of your multicolor analysis.? Free Attune NxT software with researcher-inspired upgrades? New green laser option for expanded utility and fluorochrome options? Simple push...
型號：
時間： 2019 - 04 - 17
描述The 2018 Attune NxT Acoustic Focusing Cytometer has expanded functionalities to drive your research forward. Designed and developed to remove common barriers associated with flow cytometry, the evolutionary capabilities of the Attune NxT flow cytometer offer adaptable optical configuration options so you can get the most out of your multicolor analysis.? Free Attune NxT software with researcher-inspired upgrades? New green laser option for expanded utility and fluorochrome options? Simple push...
型號：
時間： 2019 - 04 - 17
描述The 2018 Attune NxT Acoustic Focusing Cytometer has expanded functionalities to drive your research forward. Designed and developed to remove common barriers associated with flow cytometry, the evolutionary capabilities of the Attune NxT flow cytometer offer adaptable optical configuration options so you can get the most out of your multicolor analysis.? Free Attune NxT software with researcher-inspired upgrades? New green laser option for expanded utility and fluorochrome options? Simple push...
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