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1
2018 - 06 - 22
對創(chuàng)傷經(jīng)歷的回憶會導(dǎo)致精神健康問題,如創(chuàng)傷后應(yīng)激障礙(PTSD),這會破壞一個人的生活。據(jù)估計,當(dāng)前將近三分之一的人會在他們生命中的某個時刻遭受恐懼或應(yīng)激相關(guān)的障礙。如今,一項新的研究在細胞水平展示了一種療法如何能夠治療長期的創(chuàng)傷記憶。相關(guān)研究結(jié)果發(fā)表在2018年6月15日的Science期刊上,論文標題為“Reactivation of recall-induced neurons contributes to remote fear memory attenuation”。論文通信作者、瑞士洛桑聯(lián)邦理工學(xué)院(EPFL)教授Johannes Gräff說,“我們的研究結(jié)果首次揭示了讓成功治療創(chuàng)傷記憶變得可能的過程。” 在治療創(chuàng)傷記憶領(lǐng)域,對恐懼衰減(fear attenuation)是否涉及通過新的安全記憶痕跡(memory trace of safety)或?qū)⒃嫉目謶钟洃浐圹E(memory trace of fear)重寫為安全記憶痕跡來抑制原始的恐懼記憶痕跡,人們長期以來爭論不止。圖片來自EPFL / Gräff Group。這種爭論的一部分與我們總體上還不能完全理解神經(jīng)元如何存儲記憶的事實相關(guān)。雖然這項研究取得的新發(fā)現(xiàn)不能排除這種抑制機制,但是它們首次證實了重寫創(chuàng)傷記憶在治療創(chuàng)傷記憶中的重要性。這個領(lǐng)域的研究重點在于理解大腦減少創(chuàng)傷記憶的能力...
2
2019 - 04 - 12
4 月 9 日,美國紐約市市長比爾 · 德 · 布拉西奧宣布,該市布魯克林區(qū)的威廉斯堡進入緊急狀態(tài),讓當(dāng)?shù)孛癖娨粫r風(fēng)聲鶴唳。是什么導(dǎo)致政府宣布這一近年罕見的公共衛(wèi)生緊急情況?答案你或許想不到,肇事者居然是為我們熟知的一種疾病——麻疹。卷土重來,美多地暴發(fā)麻疹疫情麻疹傳染性極強,多見于兒童。我國在 1965 年后進行針對性疫苗接種的推廣,這種疾病發(fā)病率逐漸減少。在美國,本已消失的麻疹病例在近些年時有出現(xiàn),今年在個別地區(qū)更是呈大暴發(fā)之勢。美國疾病控制中心(CDC)數(shù)據(jù)顯示,截至 4 月 4 日,美國 19 個州統(tǒng)計共出現(xiàn) 465 個麻疹病例,成為 2000 年以來疫情第二嚴重年份(2014 年全美病例達 667 例)。而紐約的布魯克林則成為重災(zāi)區(qū),僅威廉斯堡這一社區(qū)從去年 10 月至今年 4 月 8 日就有 228 例確診病例。除紐約市外,紐約州、新澤西州、華盛頓州、密歇根州以及加州等多個地區(qū)出現(xiàn)了 3 例以上的麻疹病例。而 CDC 將一地區(qū)出現(xiàn) 3 例以上麻疹病例定義為疫情暴發(fā)。一時間,麻疹疫情成為美國公共衛(wèi)生領(lǐng)域最受關(guān)注的話題。推波助瀾,“反疫苗運動” 難辭其咎CDC 認為,美國的麻疹疫情與從以色列、烏克蘭和菲律賓等國來美旅客有關(guān),這些國家正在暴發(fā)大規(guī)模麻疹疫情。而對于紐約市布魯克林區(qū)來說,麻疹疫情的暴發(fā)則要歸咎于人們的錯誤認知。一場愈演愈烈的 “反疫苗運動”,...
3
2019 - 08 - 23
2019年8月23日訊 /生物谷BIOON /——2019年6月,歐洲大部分地區(qū)遭遇了早期熱浪,法國的氣溫達到了創(chuàng)紀錄的46攝氏度(115華氏度)。熱浪的特點是在幾天幾夜持續(xù)高溫。它們對我們的日常生活有重要的影響--我們感到過熱和疲勞。當(dāng)熱浪來襲時,許多政府會啟動一項'熱行動計劃',建議受影響的人多喝水,避免劇烈運動,保持涼爽。如果不這樣做,就有中暑的風(fēng)險,而中暑有可能危及生命。但是,人體究竟是如何應(yīng)對如此極端的溫度的呢?為什么高溫如此危險呢?哪些器官受到影響,什么時候情況會變得更糟?圖片來源:http://cn.bing.com保持涼爽人體的核心溫度通常在36到38攝氏度之間波動(97到99華氏度)。在這個溫度范圍內(nèi),生化反應(yīng)可以正常進行,這對細胞和器官的正常功能至關(guān)重要。人類的身體也能很好地應(yīng)對各種可能威脅其核心溫度的環(huán)境條件。當(dāng)核心溫度偏離正常范圍時,身體就會啟動生理反應(yīng),使溫度恢復(fù)正常。這種溫度調(diào)節(jié)反應(yīng)相當(dāng)于你家的恒溫器;一旦內(nèi)部溫度偏離理想溫度,加熱或冷卻系統(tǒng)就會被激活,回到理想溫度。在人體中,這個恒溫器位于我們大腦的底部,一個叫做下丘腦的區(qū)域。位于我們皮膚、肌肉和其他器官的溫度傳感器提供的信息被分析,必要時,啟動生理反應(yīng)。對溫度升高的第一個也是最重要的反應(yīng)是通過我們身體的皮膚和四肢,如手和腳散熱。我們開始產(chǎn)生汗液,汗液會在皮膚上蒸發(fā),在這個過程中散熱。這...
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時間: 2021 - 11 - 05
儀器簡介:KingFisher Flex基于磁棒式轉(zhuǎn)移磁珠技術(shù),最高通量每批同時處理96個樣品,僅需15-40分鐘(根據(jù)具體樣品和 程序),使您從繁瑣的樣品提取工作中解脫,并獲得高質(zhì)量的產(chǎn)物,為下游檢測帶來精確結(jié)果。規(guī)格參數(shù):技術(shù)原理KingFisher磁棒轉(zhuǎn)移磁珠技術(shù)控制模式單機獨立運行;通過電腦及軟件控制每批通量24/48/96溫控范圍室溫+5~+115℃磁頭類型24DW磁頭、96DW磁頭、96KF磁頭、96PCR磁頭 溫度準確性±1℃,up to +80℃;±2℃,up to+115℃磁棒類型末端充磁的非拼接式一體化永磁棒溫控方式軟件設(shè)置,每個板位均可實現(xiàn)溫控磁套裝卸軟件控制,自動裝卸計算機接口USB接口或RS-232C串口適用板型KF24深孔板、KF96深孔板、KF96淺孔板、96PCR板試劑兼容性通用磁珠試劑,無品牌限制工作體積20-5,000µL/孔軟件BindIt3.3.1,可免費升級提取板位8個自動化兼容可與機械臂、移液工作站等周邊設(shè)備整合操作界面LCD彩色顯示屏,圖形化用戶界面外部尺寸680x600x380mm(WxDxH)儀器...
產(chǎn)品名稱: K3 Plus酶標儀
型號:
時間: 2019 - 05 - 23
型號:
時間: 2019 - 04 - 22
描述The LIVE/DEAD? Fixable Green Dead Cell Stain Kit is used to determine the viability of cells prior to the fixation and permeabilization required for intracellular antibody staining or prior to elimination of biohazardous materials using formaldehyde fixation. This kit has been optimized and validated for use with a blue laser flow cytometer.? Stable—dyes are freeze dried in separate vials to maintain stability? Robust—staining pattern is the same before and after fixation? Bright signal—allows...
型號:
時間: 2019 - 04 - 18
描述This product detects the externalization of phosphatidylserine in apoptotic cells using recombinant annexin V conjugated to green-fluorescent FITC dye and dead cells using propidium iodide (PI). Propidium iodide stains necrotic cells with red fluorescence. After treatment with both probes, apoptotic cells show green fluorescence, dead cells show red and green fluorescence, and live cells show little or no fluorescence.
型號:
時間: 2019 - 04 - 18
描述SYTOX® Green nucleic acid stain is an excellent green-fluorescent nuclear and chromosome counterstain that is impermeant to live cells, making it a useful indicator of dead cells within a population.?  Impermeant to live cells?  Excitation/Emission: 504/523 nm?  Use with 488 Argon-ion laser?  Works with mammalian cells and both Gram-positive and Gram-negative bacteriaSimple Viability Determination SYTOX® Green allows quick determination of cell viability when usin...
型號:
時間: 2019 - 04 - 18
描述Premo? FUCCI Cell Cycle Sensor is a fluorescent, two-color sensor of cell cycle progression and division in live cells. It allows accurate and sensitive cell cycle analysis of individual cells or a population of cells by fluorescence microscopy, flow cytometry, or high-content imaging.At 2 x 200 µL, this is a smaller pack size version (1/5 volume) of the popular full-size product and perfect for testing its performance in your system.The Premo? FUCCI Cell Cycle Sensor is delivered by high...
型號:
時間: 2019 - 04 - 18
描述CountBright? absolute counting beads are a calibrated suspension of microspheres that are brightly fluorescent across a wide range of excitation and emission wavelengths (UV to 635 nm excitation and 385-800 nm emission). CountBright? absolute counting beads are mixed with the cell sample and assayed via flow cytometry. By comparing the ratio of bead events to cell events, absolute numbers of cells in the sample can be calculated. Because CountBright? beads are mixed in the test sample, absolut...
型號:
時間: 2019 - 04 - 17
描述CellTrace? CFSE Cell Proliferation Kit is used for in vitro and in vivo labeling of cells to trace multiple generations using dye dilution by flow cytometry.? Superior performance—bright, single-peak staining enables visualization of multiple generations? Long-term signal stability—well-retained in cells for several days post stain? Non-toxic—staining does not adversely effect cell health? Simple, robust staining protocolView a selection guide for all CellTrace? Cell Proliferation Kits fo...
型號:
時間: 2019 - 04 - 17
描述CellTrace? CFSE 細胞增殖試劑盒 (CellTrace? CFSE Cell Proliferation Kit) 以方便的一次性瓶裝形式提供用途廣泛,穩(wěn)定性高的細胞示蹤劑。 羧基熒光素二醋酸鹽琥珀酰亞胺酯,常稱為 CFSE,可被動擴散進入細胞。 這種試劑沒有顏色和熒光,直至細胞內(nèi)的酯酶去除其醋酸鹽基團,產(chǎn)生能發(fā)出明亮熒光的羧基熒光素琥珀酰亞胺酯。 琥珀酰亞胺酯與細胞內(nèi)氨基反應(yīng),形成穩(wěn)定且能用醛固定劑固定的熒光偶聯(lián)物。 此試劑盒包含十份一次性瓶裝的 CFSE,因此進行小規(guī)模實驗時無需制備過量的易變質(zhì) CFSE 儲存液。 此試劑盒還包括高質(zhì)量的 DMSO(二甲基亞砜)和詳細的實驗方案。For Research Use Only. Not for use in diagnostic procedures.圖表Suppressive capacity of isolated Treg cells.Suppressive capacity of isolated Treg cells. (A) CD4+ CD25–cells were stained with Ca...
型號:
時間: 2019 - 04 - 17
描述The Click-iT® EdU Pacific Blue? Flow Cytometry Assay Kit provides a simplified, more robust assay for analyzing DNA replication in proliferating cells as compared to traditional BrdU methods. Newly synthesized DNA is analyzed using the 405 nm laser of the flow cytometer.? Accurate—superior results compared to BrdU assays? Fast—results in as little as 90 minutes? Economical—more assays per kitView selection guide for all Click-iT? EdU and Click-iT? Plus EdU assays for flow c...
型號:
時間: 2019 - 04 - 17
描述The 2018 Attune NxT Acoustic Focusing Cytometer has expanded functionalities to drive your research forward. Designed and developed to remove common barriers associated with flow cytometry, the evolutionary capabilities of the Attune NxT flow cytometer offer adaptable optical configuration options so you can get the most out of your multicolor analysis.? Free Attune NxT software with researcher-inspired upgrades? New green laser option for expanded utility and fluorochrome options? Simple push...
型號:
時間: 2019 - 04 - 17
描述The 2018 Attune NxT Acoustic Focusing Cytometer has expanded functionalities to drive your research forward. Designed and developed to remove common barriers associated with flow cytometry, the evolutionary capabilities of the Attune NxT flow cytometer offer adaptable optical configuration options so you can get the most out of your multicolor analysis.? Free Attune NxT software with researcher-inspired upgrades? New green laser option for expanded utility and fluorochrome options? Simple push...
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