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2019 - 02 - 13

日前，《分子植物》（Molecular Plant）在線發(fā)表了中國農(nóng)業(yè)科學(xué)院油料作物研究所王漢中院士團(tuán)隊(duì)最新成果。該團(tuán)隊(duì)在國際上首次成功克隆了農(nóng)作物種子性狀的第一個(gè)細(xì)胞質(zhì)調(diào)控基因 orf188，并揭示了該基因調(diào)控油菜種子高含油量的作用機(jī)制。該成果為油菜高含油量育種提供了新途徑，為育種過程中雜交母本的選擇提供了理論支撐，對于農(nóng)作物不同類型細(xì)胞質(zhì)的應(yīng)用具有重要的指導(dǎo)意義。含油量是油菜產(chǎn)油量最重要的構(gòu)成因子之一，隨著現(xiàn)代育種對含油量潛力的不斷挖掘，提高品種的含油量越來越困難。該團(tuán)隊(duì)在油菜含油量遺傳研究的基礎(chǔ)上，從細(xì)胞質(zhì)效應(yīng)著手對含油量母體調(diào)控新機(jī)制研究取得突破，篩選到兩個(gè)對含油量具有極顯著細(xì)胞質(zhì)正負(fù)效應(yīng)的品種，鑒定出特異基因 orf188 控制細(xì)胞質(zhì)的含油量正效應(yīng)，過表達(dá)該基因可以大幅度提升含油量。研究表明，orf188 為 nap（nap-like）型油菜品種所特有基因，是一個(gè)新近進(jìn)化形成的嵌合基因。該團(tuán)隊(duì)十余年來圍繞油菜種子性狀的母體調(diào)控進(jìn)行系統(tǒng)研究，此次對細(xì)胞質(zhì)基因調(diào)控種子含油量機(jī)理的揭示，是該團(tuán)隊(duì)繼發(fā)現(xiàn)角果皮發(fā)育調(diào)控種子粒重和含油量之后發(fā)現(xiàn)的又一條母體調(diào)控新途徑，進(jìn)一步豐富和完善了種子性狀的母體調(diào)控理論，也為其他農(nóng)作物性狀細(xì)胞質(zhì)效應(yīng)的解析提供了借鑒。相關(guān)論文信息：DOI:10.1016/j.molp.2019.01.012來源：中國科學(xué)報(bào)轉(zhuǎn)載：生物360

AI技術(shù)在醫(yī)學(xué)影像中的應(yīng)用現(xiàn)狀及行業(yè)發(fā)展情況分析

2019 - 06 - 14

隨著技術(shù)飛速發(fā)展、醫(yī)學(xué)數(shù)據(jù)的持續(xù)擴(kuò)增以及硬件設(shè)備的不斷提升，人工智能和醫(yī)療的結(jié)合方式越來越多樣化。目前AI在醫(yī)療領(lǐng)域中的落地的應(yīng)用場景主要有醫(yī)學(xué)影像、智能診療、智能導(dǎo)診、智能語音、健康管理、病例分析、醫(yī)院管理、新藥研發(fā)和醫(yī)療機(jī)器人等，其中在醫(yī)學(xué)影像中的應(yīng)用最為廣泛。一、影像醫(yī)學(xué)發(fā)展現(xiàn)狀醫(yī)學(xué)影像是醫(yī)生完成診斷的主要依據(jù)，通過對影像的分析和比較，從而完成有依據(jù)的診斷。但是在實(shí)際過程中，往往會(huì)存在以下問題：（1）影像學(xué)診斷人才資源緊缺。醫(yī)療機(jī)構(gòu)普遍缺乏高水平的影像醫(yī)師，在疾病診斷時(shí)往往會(huì)發(fā)生同病異影，異病同影等情況。（2）傳統(tǒng)定性分析存在診斷誤差。醫(yī)生普遍擅長定性分析，很多微小的定量變化無法通過肉眼判斷，很難做到定量分析。（3）醫(yī)生閱片時(shí)間長。目前的影像呈現(xiàn)方式為數(shù)據(jù)和圖像，而不是最有效的信息，很大程度上限制了醫(yī)生的人工閱片速度。二、AI+醫(yī)學(xué)影像助力疾病診斷通過引入人工智能可有效解決部分問題，目前人工智能在醫(yī)學(xué)影像領(lǐng)域的應(yīng)用方向主要以下幾類：1. 影像設(shè)備的圖像重建AI可以通過算法的圖像映射技術(shù)，將采集的少量信號(hào)恢復(fù)出與全采樣圖像同樣質(zhì)量的圖像，而且使用圖像重建技術(shù)，可以由低劑量的CT和PET圖像重建得到高劑量質(zhì)量圖像。這樣在滿足臨床診斷需求的同時(shí)，還能夠降低輻射的風(fēng)險(xiǎn)。2. 智能輔助診斷疾?。?）智能輔助診斷肺部疾病國內(nèi)應(yīng)用AI+CT影像最為成熟的領(lǐng)域在肺結(jié)節(jié)的識(shí)別上。AI能夠有效識(shí)...

研究揭示多動(dòng)癥兒童前瞻記憶功能的特點(diǎn)

2019 - 12 - 25

前瞻記憶是指個(gè)體記住未來要完成任務(wù)的能力。兒童進(jìn)入學(xué)校后，前瞻記憶任務(wù)逐漸增多，對前瞻記憶能力的要求也逐漸增高。前瞻記憶任務(wù)成功的關(guān)鍵在于當(dāng)個(gè)體看到線索時(shí)能主動(dòng)提取并執(zhí)行意圖。前瞻記憶線索分為三種，時(shí)間線索（如周六晚上7點(diǎn)記得參加朋友的生日聚會(huì)）、事件線索（如路過超市記得買水果）和活動(dòng)結(jié)束線索（如寫完作業(yè)記得找家長簽字）。三種線索的提取難度存在差異，這可能與其對注意資源的需求不同有關(guān)。較之正常發(fā)育的兒童，多動(dòng)癥兒童在日常活動(dòng)中常有注意力不集中和健忘的表現(xiàn)，提示其前瞻記憶能力可能存在缺損。然而，對多動(dòng)癥兒童前瞻記憶功能的研究較少，更缺乏研究直接考察多動(dòng)癥兒童在三種線索條件下的前瞻記憶表現(xiàn)及其認(rèn)知加工特點(diǎn)。因此，中國科學(xué)院心理研究所心理健康重點(diǎn)實(shí)驗(yàn)室神經(jīng)心理和應(yīng)用認(rèn)知神經(jīng)科學(xué)（NACN）實(shí)驗(yàn)室陳楚僑研究組與北醫(yī)六院醫(yī)生錢英、濰坊醫(yī)學(xué)院教授王艷郁合作考察了多動(dòng)癥兒童在時(shí)間、事件和活動(dòng)結(jié)束線索條件下的前瞻記憶表現(xiàn)。該研究招募了28名臨床診斷的多動(dòng)癥兒童和28名年齡和性別匹配的正常發(fā)育兒童，采用釣魚游戲任務(wù)(Yang， Chan， Shum， 2011)測查兒童在三種線索條件下的前瞻記憶功能。該任務(wù)采取經(jīng)典的雙任務(wù)范式，主任務(wù)要求兒童釣魚，并同時(shí)關(guān)注前瞻記憶線索，在線索出現(xiàn)時(shí)兒童需要停止釣魚并執(zhí)行前瞻記憶任務(wù)。在時(shí)間線索條件下，兒童要記得每到整分鐘就喂貓吃魚；在事件線索條件下，兒童看到特殊條...

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產(chǎn)品名稱： EVOS? Vessel Holder, universal

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時(shí)間： 2019 - 04 - 15

描述EVOS® vessel holders allow a perfect fit of your microscope slide, cell culture flask or dish, or micro-well plate to the stage of the EVOS® imaging systems for increased precision in sample alignment. This particular vessel holder has a 25.4 mm opening and accommodates most vessel types. It is just one of many easy-to-change vessel holders and stage plates available for this instrument platform. With a snug and secure fit, yet readily switched, these accessories make imaging samp...

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產(chǎn)品名稱： EVOS? Vessel Holder, Greiner T-75 flask

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時(shí)間： 2019 - 04 - 15

描述EVOS® vessel holders allow a perfect fit of your microscope slide, cell culture flask or dish, or micro-well plate to the stage of the EVOS® imaging systems for increased precision in sample alignment. This particular vessel holder accommodates one Greiner T-75 flask. It is just one of many easy-to-change vessel holders and stage plates available for this instrument platform. With a snug and secure fit, yet readily switched, these accessories make imaging samples in a range of ves...

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產(chǎn)品名稱： EVOS? Vessel Holder, Hemocytometer

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時(shí)間： 2019 - 04 - 15

描述EVOS® vessel holders allow a perfect fit of your microscope slide, cell culture flask or dish, or micro-well plate to the stage of the EVOS® imaging systems for increased precision in sample alignment. This particular vessel holder accommodates a hemocytometer. It is just one of many easy-to-change vessel holders and stage plates available for this instrument platform. With a snug and secure fit, yet readily switched, these accessories make imaging samples in a range of vessel hol...

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產(chǎn)品名稱： EVOS? Vessel Holder, Nunc? T-75 flask

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時(shí)間： 2019 - 04 - 15

描述EVOS® vessel holders allow a perfect fit of your microscope slide, cell culture flask or dish, or micro-well plate to the stage of the EVOS® imaging systems for increased precision in sample alignment. This particular vessel holder accommodates one Nunc® T-75 flask. It is just one of many easy-to-change vessel holders and stage plates available for this instrument platform. With a snug and secure fit, yet readily switched, these accessories make imaging samples in a range of ...

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產(chǎn)品名稱： EVOS? Vessel Holder, two 25-cm T-flasks

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時(shí)間： 2019 - 04 - 15

描述EVOS® vessel holders allow a perfect fit of your microscope slide, cell culture flask or dish, or micro-well plate to the stage of the EVOS® imaging systems for increased precision in sample alignment. This particular vessel holder accommodates two 25 cm T-flasks. It is just one of many easy-to-change vessel holders and stage plates available for this instrument platform. With a snug and secure fit, yet readily switched, these accessories make imaging samples in a range of vessel ...

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產(chǎn)品名稱： EVOS? Vessel Holder, one 100-mm Petri dish

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時(shí)間： 2019 - 04 - 15

描述EVOS® vessel holders allow a perfect fit of your microscope slide, cell culture flask or dish, or micro-well plate to the stage of the EVOS® imaging systems for increased precision in sample alignment. This particular vessel holder accommodates one 100 mm Petri dish. It is just one of many easy-to-change vessel holders and stage plates available for this instrument platform. With a snug and secure fit, yet readily switched, these accessories make imaging samples in a range of vess...

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產(chǎn)品名稱： EVOS? Vessel Holder, two 60-mm Petri dishes

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時(shí)間： 2019 - 04 - 15

描述EVOS® vessel holders allow a perfect fit of your microscope slide, cell culture flask or dish, or micro-well plate to the stage of the EVOS® imaging systems for increased precision in sample alignment. This particular vessel holder accommodates two 60 mm Petri dishes. It is just one of many easy-to-change vessel holders and stage plates available for this instrument platform. With a snug and secure fit, yet readily switched, these accessories make imaging samples in a range of ves...

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產(chǎn)品名稱： EVOS? Vessel Holder, four 35-mm Petri dishes

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時(shí)間： 2019 - 04 - 12

描述EVOS® vessel holders allow a perfect fit of your microscope slide, cell culture flask or dish, or micro-well plate to the stage of the EVOS® imaging systems for increased precision in sample alignment. This particular vessel holder accommodates four 35 mm Petri dishes. It is just one of many easy-to-change vessel holders and stage plates available for this instrument platform. With a snug and secure fit, yet readily switched, these accessories make imaging samples in a range of ve...

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產(chǎn)品名稱： EVOS? Vessel Holder, two 25 x 75 mm slides

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時(shí)間： 2019 - 04 - 12

描述EVOS® vessel holders allow a perfect fit of your microscope slide, cell culture flask or dish, or micro-well plate to the stage of the EVOS® imaging systems for increased precision in sample alignment. This particular vessel holder accommodates two 25 x 75 mm slides. It is just one of many easy-to-change vessel holders and stage plates available for this instrument platform. With a snug and secure fit, yet readily switched, these accessories make imaging samples in a range of vess...

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產(chǎn)品名稱： EVOS? 4X Objective, fluorite, LWD, phase-contrast

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時(shí)間： 2019 - 04 - 12

描述This fluorite objective is ideal for fluorescence and demanding transmitted-light applications. This is a long working distance (LWD) objective that is optimized for the imaging of slides, cell culture dishes and flasks, and microtiter plates. This is also a phase-contrast objective, making it useful for hard-to-see, translucent speciments. All EVOS® objectives offer outstanding optical performance from visible light to near infrared light. The extensive choice of objectives satisfies nee...

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產(chǎn)品名稱： EVOS? Light Cube, Cy?5

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時(shí)間： 2019 - 04 - 12

描述All EVOS® fluorescence imaging systems and the Countess® II FL Automated Cell Counter contain our unique, proprietary LED light cubes. This world-leading light engine outputs remarkable intensity over a short light path that delivers superior fluorophore excitation. Each cube contains an LED, condensing optics, and hard-coated filters. EVOS® light cubes are user-changeable and automatically recognized by the system. The Cy®5 light cube is ideal for use with Alexa Fluor&...

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產(chǎn)品名稱： EVOS? Light Cube, RFP

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時(shí)間： 2019 - 04 - 12

描述All EVOS® fluorescence imaging systems and the Countess® II FL Automated Cell Counter contain our unique, proprietary LED light cubes. This world-leading light engine outputs remarkable intensity over a short light path that delivers superior fluorophore excitation. Each cube contains an LED, condensing optics, and hard-coated filters. EVOS® light cubes are user-changeable and automatically recognized by the system. The RFP light cube is ideal for use with Alexa Fluor® ...

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