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4
2020 - 05 - 08
最近，《自然—通訊》刊發(fā)了一篇針對(duì)類風(fēng)濕關(guān)節(jié)炎（RA）致病和標(biāo)志分子的研究。該文章來自北京大學(xué)人民醫(yī)院風(fēng)濕免疫研究所栗占國課題組，作者發(fā)現(xiàn)，RA患者的sSR-A水平顯著升高，與該疾病的臨床癥狀和免疫狀況指標(biāo)直接相關(guān)。結(jié)果表明sSR-A是RA診斷的新型生物標(biāo)志物，尤其可用于血清陰性及早期RA的診斷，而靶向sSR-A可能是一種新的治療策略?！吨袊茖W(xué)報(bào)》了解到，RA是一種常見的自身免疫病，具有高致殘性。全球有3000多萬患者，該病以破壞性關(guān)節(jié)炎及自身免疫異常為主要特征。目前，RA的血清診斷主要依據(jù)類風(fēng)濕因子和抗CCP的檢測(cè)。但是，仍有大量患者在發(fā)病初期，甚至患病多年而缺乏生物標(biāo)志物，給臨床診斷和治療帶來困難，導(dǎo)致延誤治療而出現(xiàn)殘疾。早期診斷對(duì)于改善RA的結(jié)局至關(guān)重要。但是，目前的診斷工具對(duì)早期患者敏感性有限，致使大量的患者因延誤診斷，不能得以正確治療，出現(xiàn)殘疾。鑒于此，該研究團(tuán)隊(duì)聯(lián)合浙江大學(xué)、南方醫(yī)科大學(xué)和包頭醫(yī)學(xué)院的研究者展開了一項(xiàng)大規(guī)模的多中心研究，涉及3262名參與者的訓(xùn)練隊(duì)列和驗(yàn)證隊(duì)列，最終發(fā)現(xiàn)sSR-A是RA的致病分子，可促進(jìn)炎性T細(xì)胞和致炎因子產(chǎn)生。并且，該課題組利用基因敲除的sSR-A-/-模型研究證明，sSR-A可以促進(jìn)關(guān)節(jié)炎的發(fā)病以及病情的加重，靶向抑制sSR-A可以緩解關(guān)節(jié)炎的癥狀。研究者進(jìn)一步證實(shí)，sSR-A蛋白可以促進(jìn)膠原誘導(dǎo)性關(guān)節(jié)炎發(fā)病，加速病情進(jìn)展，加重疾病...
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2018 - 06 - 14
2018年6月13日訊 /生物谷BIOON/ --阿爾茨海默氏癥（AD）一直是新藥研發(fā)的重災(zāi)區(qū)，該領(lǐng)域研發(fā)失敗率高達(dá)99.6%。過去幾年，包括禮來、阿斯利康、強(qiáng)生、輝瑞、羅氏在內(nèi)的制藥巨頭投資達(dá)數(shù)十億美元之巨的多個(gè)單抗藥物均在III期臨床慘遭失敗，為該領(lǐng)域的投資前景蒙上了厚厚的陰云。之后，另一個(gè)很有前途的新藥類別——BACE抑制劑，成功取代抗體藥物站在了AD研發(fā)的舞臺(tái)中央。然而，BACE抑制劑似乎也不大可能打破魔咒，正在追隨著單抗藥物的步伐。去年情人節(jié)當(dāng)天，BACE抑制劑領(lǐng)域的領(lǐng)頭羊——默沙東宣布終止verubecestat治療輕至中度AD的大型III期研究EPOCH（protocol 017）；今年情人節(jié)前一天，默沙東再次宣布終止verubecestat治療前驅(qū)期AD的大型III期研究APECS(protocol 019)。這也意味著，verubecestat治療AD的III期臨床項(xiàng)目已完全終止。而2次公告時(shí)間均選在情人節(jié)，特別耐人尋味，默沙東似乎在述說著心中的苦楚和不舍，而這一點(diǎn)，一大票巨頭們都深有感觸：AD，AD，想說愛你，真的不易o(hù)(╥﹏╥)o！就在昨天，禮來和阿斯利康哥倆，手牽手沿著BACE國道，哭喊著朝默沙東奔去，原因竟然是——————————他們的BACE抑制劑也O-O-O-O-OVER了?。。「鶕?jù)公告，雙方將終止lanabecestat的全球III期項(xiàng)目，包括lan...
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2019 - 04 - 04
英國國家醫(yī)療服務(wù)系統(tǒng)（NHS）近日批準(zhǔn)了三種新的甲狀腺癌療法作為甲狀腺癌的常規(guī)療法。由國家健康和護(hù)理研究所（NICE）提出的推薦指南建議把cabozantinib（Cometriq）和索拉菲尼sorafenib（Nexavar）轉(zhuǎn)移進(jìn)癌癥藥物基金。被批準(zhǔn)的第三種藥物是樂伐替尼（Lenvatinib/Lenvima），過去這個(gè)藥物僅僅在出于同情的情況下提供使用。英國癌癥研究中心的高級(jí)政策顧問Rose Gray對(duì)這些決定感到高興，他認(rèn)為這對(duì)于病人而言是好消息。病人選擇有限！Cabozantinib被推薦用于治療無法進(jìn)行手術(shù)治療或者已經(jīng)轉(zhuǎn)移的甲狀腺髓樣癌。英國每年約有80例這種病人。Gray說臨床結(jié)果顯示Cabozantinib能夠延緩癌癥進(jìn)展。這是僅有的治療甲狀腺髓樣癌的兩種藥物之一。Lenvatinib和sorafenib被批準(zhǔn)用于治療手術(shù)或者放射性碘治療無效的分化型甲狀腺癌，這是最常見的種類。手術(shù)或者放射性碘治療后，這兩種藥物是這些病人的唯二選擇。每年英國約有200人能由于這兩種藥物獲益。Lenvatinib和sorafenib比通常認(rèn)為可以接受的效果差一點(diǎn)，但是在病人報(bào)道他們生活質(zhì)量得到改善后，NICE批準(zhǔn)了這兩種藥物?！癗ICE從一些病人口中聽說了這些藥物如何改善癥狀，這表明這些藥物在癌癥病人身上的價(jià)值。”Gray說道。NICE健康技術(shù)評(píng)估中心執(zhí)行主任Mirella Marlo...
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時(shí)間： 2019 - 04 - 17
描述The 2018 Attune NxT Acoustic Focusing Cytometer has expanded functionalities to drive your research forward. Designed and developed to remove common barriers associated with flow cytometry, the evolutionary capabilities of the Attune NxT flow cytometer offer adaptable optical configuration options so you can get the most out of your multicolor analysis.? Free Attune NxT software with researcher-inspired upgrades? New green laser option for expanded utility and fluorochrome options? Simple push...
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時(shí)間： 2019 - 04 - 17
描述The 2018 Attune NxT Acoustic Focusing Cytometer has expanded functionalities to drive your research forward. Designed and developed to remove common barriers associated with flow cytometry, the evolutionary capabilities of the Attune NxT flow cytometer offer adaptable optical configuration options so you can get the most out of your multicolor analysis.? Free Attune NxT software with researcher-inspired upgrades? New green laser option for expanded utility and fluorochrome options? Simple push...
產(chǎn)品名稱： 7-AAD (7-Aminoactinomycin D)
型號(hào)：
時(shí)間： 2019 - 04 - 17
描述7-aminoactinomycin D (7-AAD) is a fluorescent intercalator that undergoes a spectral shift upon association with DNA. 7-AAD/DNA complexes can be excited by the 488 nm laser and has an emission maxima of 647 nm, making this nucleic acid stain useful for multicolor fluorescence microscopy and flow cytometry. 7-AAD appears to be generally excluded from live cells, but can be used with cells that have been fixed and permeabilized. 7-AAD has been used for cell cycle analysis by flow cytometry....
產(chǎn)品名稱： Dynabeads? CD45
型號(hào)：
時(shí)間： 2019 - 04 - 17
DescriptionDynabeads® CD45 are superparamagnetic beads covalently coupled to anti-human CD45 antibody that enable isolation or depletion of CD45+ leucocytes directly from whole blood, buffy coat, or MNC suspensions. Dynabeads® CD45 can also be used to enrich epithelial tumor cells. The CD45 antigen is weakly expressed on myeloid cells. To efficiently deplete or isolate all leucocytes including myeloid cells, use Dynabeads® CD15 (Cat. No. 11137D) in combination with Dynabeads®...
型號(hào)：
時(shí)間： 2019 - 04 - 15
描述This achromat objective is ideal for general applications. This is a coverslip-corrected objective that is optimized for imaging through #1.5 coverslips. All EVOS® objectives offer outstanding optical performance from visible light to near infrared light. The extensive choice of objectives satisfies needs across the spectrum of magnifications and optical specifications.Additional characteristics of this EVOS® objective:? Magnification: 50X? Numerical Aperture: 0.95? Working Distance:...
產(chǎn)品名稱： EVOS? M7000 Imaging System
型號(hào)：
時(shí)間： 2019 - 04 - 15
描述The EVOS M7000 Imaging System is a high-performance, fully automated, inverted, multi-channel fluorescence and transmitted light imaging system. It was developed to meet today’s expectations for image quality, user interface interactions, data generation speed and flexibility, and end-user value. The powerful and time-saving acquisition tools with enhanced autofocus algorithms and automated routines for microwell plate assays, time-lapse live cell imaging, area scanning in time lapse and Z-sta...
產(chǎn)品名稱： EVOS? FL Imaging System
型號(hào)：
時(shí)間： 2019 - 04 - 15
描述The EVOS® FL Imaging System is a fully integrated, digital, inverted imaging system for four-color fluorescence and transmitted-light applications. It is powerful, yet easy-to-use and delivers high-definition images with exceptional convenience. The unique light cubes, sensitive camera, and precision-engineered optical system make the EVOS® FL system ideal for both demanding and routine fluorescence imaging applications.The EVOS® FL Imaging System offers you these important ad...
產(chǎn)品名稱： EVOS? Onstage Master Plate
型號(hào)：
時(shí)間： 2019 - 04 - 15
描述The EVOS® Onstage Master Plate is part of the EVOS® Onstage Incubator and holds the EVOS® Onstage Vessel Holder. The EVOS® Onstage Incubator is an environmental chamber designed specifically for use with the EVOS® FL Auto Imaging System. This master plate plus vessel holder design, with vessel holders available that accommodate various types of cell culture vessels, provides flexibility in your approach to extended time-lapse imaging experiments under precisely co...
型號(hào)：
時(shí)間： 2019 - 04 - 15
描述EVOS® Onstage vessel holders maximize your choice of cell culture vessels when conducting time-lapse imaging experiments using the EVOS® FL Auto Imaging System equipped with an EVOS® Onstage Incubator. EVOS® Onstage vessel holders allow a perfect fit of your micro-well plates or cell culture flasks/dishes to the master plate of the EVOS® Onstage Incubator for increased precision in sample alignment. This particular vessel holder accommodates two 25-mL T-flasks. With ...
型號(hào)：
時(shí)間： 2019 - 04 - 15
描述EVOS® Onstage vessel holders maximize your choice of cell culture vessels when conducting time-lapse imaging experiments using the EVOS® FL Auto Imaging System equipped with an EVOS® Onstage Incubator. EVOS® Onstage vessel holders allow a perfect fit of your micro-well plates or cell culture flasks/dishes to the master plate of the EVOS® Onstage Incubator for increased precision in sample alignment. This particular vessel holder accommodates multi-well plates (dimensi...
型號(hào)：
時(shí)間： 2019 - 04 - 15
描述EVOS® vessel holders allow a perfect fit of your microscope slide, cell culture flask or dish, or micro-well plate to the stage of the EVOS® imaging systems for increased precision in sample alignment. This particular vessel holder securely holds two 25 x 75 mm standard or chamber microscope slides and is specific for the automated stage of the EVOS® FL Auto Imaging System. It is just one of many easy-to-change vessel holders and stage plates available for this instrument plat...
型號(hào)：
時(shí)間： 2019 - 04 - 15
描述EVOS® vessel holders allow a perfect fit of your microscope slide, cell culture flask or dish, or micro-well plate to the stage of the EVOS® imaging systems for increased precision in sample alignment. This particular vessel holder accommodates one Greiner/BD T-25 flask. It is just one of many easy-to-change vessel holders and stage plates available for this instrument platform. With a snug and secure fit, yet readily switched, these accessories make imaging samples in a range of ...
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