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1
2018 - 06 - 08
2018年6月6日訊 /生物谷BIOON /——PERIOD 2 (PER2)蛋白的多點(diǎn)磷酸化是決定哺乳動(dòng)物生物鐘周期的關(guān)鍵步驟。過(guò)去的研究認(rèn)為PER2被酪蛋白激酶1(CK1)磷酸化的過(guò)程需要一種未被發(fā)現(xiàn)的蛋白激酶來(lái)啟動(dòng),而CK1是一種從藻類(lèi)到人類(lèi)都高度保守的生物鐘必需蛋白。這些磷酸化過(guò)程可以穩(wěn)定PER2,延緩其降解以延長(zhǎng)生物鐘周期。圖片來(lái)源:CCO public domain為了找到這個(gè)必需的蛋白質(zhì),一個(gè)由杜克-新加坡國(guó)立大學(xué)醫(yī)學(xué)院研究人員領(lǐng)導(dǎo)的國(guó)際團(tuán)隊(duì)對(duì)小鼠PER2啟動(dòng)磷酸化的過(guò)程進(jìn)行了綜合的生物化學(xué)和生物物理學(xué)分析,結(jié)果驚訝地發(fā)現(xiàn)CK1δ/ε就是他們尋找的啟動(dòng)激酶。此外,他們還發(fā)現(xiàn)CK1ε和一個(gè)最近發(fā)現(xiàn)的CK1δ2剪接變體可以比CK1δ1更有效地啟動(dòng)磷酸化。盡管過(guò)去研究顯示CK1對(duì)PER2的磷酸化對(duì)細(xì)胞環(huán)境很不敏感,但是研究人員通過(guò)使用生物節(jié)律磷酸化開(kāi)關(guān)數(shù)學(xué)模型發(fā)現(xiàn)CK1羧基端尾部使得生物鐘周期對(duì)細(xì)胞信號(hào)敏感。這些研究表明CK1羧基端是生物節(jié)律的一個(gè)重要的調(diào)節(jié)因子。(生物谷Bioon.com)參考資料:Rajesh Narasimamurthy et al, CK1δ/ε protein kinase primes the PER2 circadian phosphoswitch, Proceedings of the National Academy of Sci...
2
2019 - 03 - 29
空氣污染有關(guān)眾所周知,污濁的空氣對(duì)身體有害,每年在全球范圍內(nèi)造成數(shù)百萬(wàn)人死亡。這使空氣污染成為比吸煙更厲害的殺手。然而,空氣污染對(duì)人類(lèi)大腦也有害嗎?一項(xiàng)研究發(fā)現(xiàn),在英國(guó)污染最嚴(yán)重地區(qū),青少年的精神疾病問(wèn)題(包括幻覺(jué))更加常見(jiàn)。相關(guān)成果日前發(fā)表于《美國(guó)醫(yī)學(xué)會(huì)雜志—精神病學(xué)》。然而,這種關(guān)聯(lián)并非意味著吸入污濁空氣會(huì)使青少年患上精神疾病,因?yàn)榭赡苓€有其他解釋。該研究作者之一、倫敦國(guó)王學(xué)院的 Helen Fisher 表示,這項(xiàng)研究未顯示出因果關(guān)系。Fisher 和同事發(fā)現(xiàn),在 2000 名 18 歲青少年中,30% 的人報(bào)告稱其在青少年時(shí)期至少有過(guò)一次精神疾病經(jīng)歷——其他針對(duì)年輕人的研究也報(bào)告了類(lèi)似數(shù)字。然而研究發(fā)現(xiàn),當(dāng)把這些青少年的住址與空氣污染情況作對(duì)照時(shí),那些生活在污染程度較高地區(qū)的青少年更有可能有精神疾病史。在氮氧化物(由柴油車(chē)產(chǎn)生的污染物)含量最高的地區(qū),每 20 名青少年中就有 12 名報(bào)告患有精神疾?。欢诳諝廨^清潔地區(qū),降至每 20 人中有 7 人患病。目前尚不清楚空氣污染與精神疾病存在何種關(guān)聯(lián)。該團(tuán)隊(duì)提出的一種推測(cè)性機(jī)制是,污染物累積會(huì)直接影響大腦。研究表明,空氣污染與額葉皮層和嗅球的炎癥和退化有關(guān),其中嗅球是大腦中負(fù)責(zé)嗅覺(jué)的部分。而大腦炎癥已被證實(shí)與精神疾病有關(guān)。一個(gè)更簡(jiǎn)單的解釋可能是,不是污染空氣本身,而是汽車(chē)排放的噪音污染帶來(lái)了問(wèn)題。噪音污染會(huì)增加壓力、擾亂睡眠,...
3
2019 - 08 - 01
第二看臺(tái)老年性黃斑變性(AMD)、視網(wǎng)膜色素變性(RP)等視網(wǎng)膜變性疾病是目前尚無(wú)有效治療手段的兇險(xiǎn)致盲性眼病,也是公認(rèn)的 “視力殺手”。由中南大學(xué)愛(ài)爾眼科學(xué)院院長(zhǎng)唐仕波教授、愛(ài)爾眼科研究所副所長(zhǎng)陳建蘇教授帶領(lǐng)團(tuán)隊(duì),利用誘導(dǎo)多能干細(xì)胞(iPS)條件培養(yǎng)基和飛秒角膜透鏡,聯(lián)合構(gòu)建高活性視網(wǎng)膜色素上皮細(xì)胞(RPE)的研究,不但有利于對(duì)視網(wǎng)膜色素上皮細(xì)胞生理特性、藥物篩選等研究,還有利于構(gòu)建組織工程視網(wǎng)膜層及其移植。這將幫助科學(xué)家開(kāi)發(fā)出應(yīng)用組織工程 RPE 細(xì)胞片治療視網(wǎng)膜變性疾病和光感受器病變的新方法。培養(yǎng)高活性的視網(wǎng)膜細(xì)胞與年齡相關(guān)的老年性黃斑變性是發(fā)達(dá)國(guó)家 50 歲以上人群視力損害和致盲的首要病因,多達(dá) 90% 的病人無(wú)法治愈。數(shù)據(jù)顯示,發(fā)達(dá)國(guó)家年齡 50 歲以上黃斑變性的發(fā)病率達(dá) 11%,目前我國(guó)的發(fā)病率接近發(fā)達(dá)國(guó)家,患病人數(shù)超過(guò) 3000 萬(wàn)人,并以每年 30 萬(wàn)人次的速度增加,成為我國(guó)現(xiàn)階段 50 歲以上年齡群體發(fā)病率最高的三大眼科疾病之一,而且女性呈現(xiàn)出比男性更高的危險(xiǎn)性。研究發(fā)現(xiàn),未來(lái)最有希望治療老年性黃斑變性的方式是視網(wǎng)膜色素上皮細(xì)胞療法、視網(wǎng)膜黃斑部分的移植。那么,要采用 RPE 療法,就需要先培養(yǎng)健康的視網(wǎng)膜細(xì)胞。陳建蘇告訴科技日?qǐng)?bào)記者,取出死亡時(shí)間在 3 小時(shí)內(nèi)捐獻(xiàn)者的帶有部分脈絡(luò)膜的視網(wǎng)膜組織,在解剖顯微鏡下可將帶有部分脈絡(luò)膜的 RPE 層從捐贈(zèng)組織中分離出來(lái),...
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時(shí)間: 2021 - 11 - 05
儀器簡(jiǎn)介:KingFisher Flex基于磁棒式轉(zhuǎn)移磁珠技術(shù),最高通量每批同時(shí)處理96個(gè)樣品,僅需15-40分鐘(根據(jù)具體樣品和 程序),使您從繁瑣的樣品提取工作中解脫,并獲得高質(zhì)量的產(chǎn)物,為下游檢測(cè)帶來(lái)精確結(jié)果。規(guī)格參數(shù):技術(shù)原理KingFisher磁棒轉(zhuǎn)移磁珠技術(shù)控制模式單機(jī)獨(dú)立運(yùn)行;通過(guò)電腦及軟件控制每批通量24/48/96溫控范圍室溫+5~+115℃磁頭類(lèi)型24DW磁頭、96DW磁頭、96KF磁頭、96PCR磁頭 溫度準(zhǔn)確性±1℃,up to +80℃;±2℃,up to+115℃磁棒類(lèi)型末端充磁的非拼接式一體化永磁棒溫控方式軟件設(shè)置,每個(gè)板位均可實(shí)現(xiàn)溫控磁套裝卸軟件控制,自動(dòng)裝卸計(jì)算機(jī)接口USB接口或RS-232C串口適用板型KF24深孔板、KF96深孔板、KF96淺孔板、96PCR板試劑兼容性通用磁珠試劑,無(wú)品牌限制工作體積20-5,000µL/孔軟件BindIt3.3.1,可免費(fèi)升級(jí)提取板位8個(gè)自動(dòng)化兼容可與機(jī)械臂、移液工作站等周邊設(shè)備整合操作界面LCD彩色顯示屏,圖形化用戶界面外部尺寸680x600x380mm(WxDxH)儀器...
產(chǎn)品名稱: K3 Plus酶標(biāo)儀
型號(hào):
時(shí)間: 2019 - 05 - 23
型號(hào):
時(shí)間: 2019 - 04 - 22
描述The LIVE/DEAD? Fixable Green Dead Cell Stain Kit is used to determine the viability of cells prior to the fixation and permeabilization required for intracellular antibody staining or prior to elimination of biohazardous materials using formaldehyde fixation. This kit has been optimized and validated for use with a blue laser flow cytometer.? Stable—dyes are freeze dried in separate vials to maintain stability? Robust—staining pattern is the same before and after fixation? Bright signal—allows...
型號(hào):
時(shí)間: 2019 - 04 - 18
描述This product detects the externalization of phosphatidylserine in apoptotic cells using recombinant annexin V conjugated to green-fluorescent FITC dye and dead cells using propidium iodide (PI). Propidium iodide stains necrotic cells with red fluorescence. After treatment with both probes, apoptotic cells show green fluorescence, dead cells show red and green fluorescence, and live cells show little or no fluorescence.
型號(hào):
時(shí)間: 2019 - 04 - 18
描述SYTOX® Green nucleic acid stain is an excellent green-fluorescent nuclear and chromosome counterstain that is impermeant to live cells, making it a useful indicator of dead cells within a population.?  Impermeant to live cells?  Excitation/Emission: 504/523 nm?  Use with 488 Argon-ion laser?  Works with mammalian cells and both Gram-positive and Gram-negative bacteriaSimple Viability Determination SYTOX® Green allows quick determination of cell viability when usin...
型號(hào):
時(shí)間: 2019 - 04 - 18
描述Premo? FUCCI Cell Cycle Sensor is a fluorescent, two-color sensor of cell cycle progression and division in live cells. It allows accurate and sensitive cell cycle analysis of individual cells or a population of cells by fluorescence microscopy, flow cytometry, or high-content imaging.At 2 x 200 µL, this is a smaller pack size version (1/5 volume) of the popular full-size product and perfect for testing its performance in your system.The Premo? FUCCI Cell Cycle Sensor is delivered by high...
型號(hào):
時(shí)間: 2019 - 04 - 18
描述CountBright? absolute counting beads are a calibrated suspension of microspheres that are brightly fluorescent across a wide range of excitation and emission wavelengths (UV to 635 nm excitation and 385-800 nm emission). CountBright? absolute counting beads are mixed with the cell sample and assayed via flow cytometry. By comparing the ratio of bead events to cell events, absolute numbers of cells in the sample can be calculated. Because CountBright? beads are mixed in the test sample, absolut...
型號(hào):
時(shí)間: 2019 - 04 - 17
描述CellTrace? CFSE Cell Proliferation Kit is used for in vitro and in vivo labeling of cells to trace multiple generations using dye dilution by flow cytometry.? Superior performance—bright, single-peak staining enables visualization of multiple generations? Long-term signal stability—well-retained in cells for several days post stain? Non-toxic—staining does not adversely effect cell health? Simple, robust staining protocolView a selection guide for all CellTrace? Cell Proliferation Kits fo...
型號(hào):
時(shí)間: 2019 - 04 - 17
描述CellTrace? CFSE 細(xì)胞增殖試劑盒 (CellTrace? CFSE Cell Proliferation Kit) 以方便的一次性瓶裝形式提供用途廣泛,穩(wěn)定性高的細(xì)胞示蹤劑。 羧基熒光素二醋酸鹽琥珀酰亞胺酯,常稱為 CFSE,可被動(dòng)擴(kuò)散進(jìn)入細(xì)胞。 這種試劑沒(méi)有顏色和熒光,直至細(xì)胞內(nèi)的酯酶去除其醋酸鹽基團(tuán),產(chǎn)生能發(fā)出明亮熒光的羧基熒光素琥珀酰亞胺酯。 琥珀酰亞胺酯與細(xì)胞內(nèi)氨基反應(yīng),形成穩(wěn)定且能用醛固定劑固定的熒光偶聯(lián)物。 此試劑盒包含十份一次性瓶裝的 CFSE,因此進(jìn)行小規(guī)模實(shí)驗(yàn)時(shí)無(wú)需制備過(guò)量的易變質(zhì) CFSE 儲(chǔ)存液。 此試劑盒還包括高質(zhì)量的 DMSO(二甲基亞砜)和詳細(xì)的實(shí)驗(yàn)方案。For Research Use Only. Not for use in diagnostic procedures.圖表Suppressive capacity of isolated Treg cells.Suppressive capacity of isolated Treg cells. (A) CD4+ CD25–cells were stained with Ca...
型號(hào):
時(shí)間: 2019 - 04 - 17
描述The Click-iT® EdU Pacific Blue? Flow Cytometry Assay Kit provides a simplified, more robust assay for analyzing DNA replication in proliferating cells as compared to traditional BrdU methods. Newly synthesized DNA is analyzed using the 405 nm laser of the flow cytometer.? Accurate—superior results compared to BrdU assays? Fast—results in as little as 90 minutes? Economical—more assays per kitView selection guide for all Click-iT? EdU and Click-iT? Plus EdU assays for flow c...
型號(hào):
時(shí)間: 2019 - 04 - 17
描述The 2018 Attune NxT Acoustic Focusing Cytometer has expanded functionalities to drive your research forward. Designed and developed to remove common barriers associated with flow cytometry, the evolutionary capabilities of the Attune NxT flow cytometer offer adaptable optical configuration options so you can get the most out of your multicolor analysis.? Free Attune NxT software with researcher-inspired upgrades? New green laser option for expanded utility and fluorochrome options? Simple push...
型號(hào):
時(shí)間: 2019 - 04 - 17
描述The 2018 Attune NxT Acoustic Focusing Cytometer has expanded functionalities to drive your research forward. Designed and developed to remove common barriers associated with flow cytometry, the evolutionary capabilities of the Attune NxT flow cytometer offer adaptable optical configuration options so you can get the most out of your multicolor analysis.? Free Attune NxT software with researcher-inspired upgrades? New green laser option for expanded utility and fluorochrome options? Simple push...
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