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7
2019 - 08 - 23
2019年8月23日訊 /生物谷BIOON /——2019年6月，歐洲大部分地區(qū)遭遇了早期熱浪，法國的氣溫達(dá)到了創(chuàng)紀(jì)錄的46攝氏度(115華氏度)。熱浪的特點(diǎn)是在幾天幾夜持續(xù)高溫。它們對(duì)我們的日常生活有重要的影響--我們感到過熱和疲勞。當(dāng)熱浪來襲時(shí)，許多政府會(huì)啟動(dòng)一項(xiàng)'熱行動(dòng)計(jì)劃'，建議受影響的人多喝水，避免劇烈運(yùn)動(dòng)，保持涼爽。如果不這樣做，就有中暑的風(fēng)險(xiǎn)，而中暑有可能危及生命。但是，人體究竟是如何應(yīng)對(duì)如此極端的溫度的呢？為什么高溫如此危險(xiǎn)呢？哪些器官受到影響，什么時(shí)候情況會(huì)變得更糟？圖片來源：http://cn.bing.com保持涼爽人體的核心溫度通常在36到38攝氏度之間波動(dòng)(97到99華氏度)。在這個(gè)溫度范圍內(nèi)，生化反應(yīng)可以正常進(jìn)行，這對(duì)細(xì)胞和器官的正常功能至關(guān)重要。人類的身體也能很好地應(yīng)對(duì)各種可能威脅其核心溫度的環(huán)境條件。當(dāng)核心溫度偏離正常范圍時(shí)，身體就會(huì)啟動(dòng)生理反應(yīng)，使溫度恢復(fù)正常。這種溫度調(diào)節(jié)反應(yīng)相當(dāng)于你家的恒溫器；一旦內(nèi)部溫度偏離理想溫度，加熱或冷卻系統(tǒng)就會(huì)被激活，回到理想溫度。在人體中，這個(gè)恒溫器位于我們大腦的底部，一個(gè)叫做下丘腦的區(qū)域。位于我們皮膚、肌肉和其他器官的溫度傳感器提供的信息被分析，必要時(shí)，啟動(dòng)生理反應(yīng)。對(duì)溫度升高的第一個(gè)也是最重要的反應(yīng)是通過我們身體的皮膚和四肢，如手和腳散熱。我們開始產(chǎn)生汗液，汗液會(huì)在皮膚上蒸發(fā)，在這個(gè)過程中散熱。這...
8
2021 - 04 - 01
2021年3月29日訊/生物谷BIOON/---肌肉干細(xì)胞可發(fā)育分化為成肌細(xì)胞(myoblasts)，后者可互相融合成為多核的肌纖維，形成骨骼肌最基本的結(jié)構(gòu)。人類胚胎和成人體內(nèi)都存在肌肉干細(xì)胞。胚胎和胎兒的肌肉干細(xì)胞增殖使得肌肉組織發(fā)展；成年人體內(nèi)的肌肉干細(xì)胞亦被稱為衛(wèi)星細(xì)胞，處于休眠狀態(tài)，沿著肌肉纖維而分布。在經(jīng)過強(qiáng)烈運(yùn)動(dòng)或是受到外界傷害之后，成人的肌肉干細(xì)胞會(huì)被激活并開始自我增殖，從而增加或是恢復(fù)成人的肌肉組織。對(duì)于老年人，肌肉干細(xì)胞不再具有自我復(fù)制的活性，從而表現(xiàn)為肌肉組織的萎縮。小編針對(duì)近年來肌肉干細(xì)胞研究取得的進(jìn)展進(jìn)行一番盤點(diǎn)，以饗讀者。1.Nature子刊：揭示一種化學(xué)物混合物可產(chǎn)生大量的肌肉干細(xì)胞doi:10.1038/s41551-021-00696-y在一項(xiàng)新的研究中，來自美國加州大學(xué)洛杉磯分校的研究人員鑒定出一種化學(xué)物混合物，它能夠大量地產(chǎn)生可以自我更新并可產(chǎn)生所有類型骨骼肌細(xì)胞的肌肉干細(xì)胞。這一進(jìn)展可能導(dǎo)致開發(fā)基于干細(xì)胞的療法，以治療因受傷、年齡或疾病而導(dǎo)致的肌肉損失或損傷。相關(guān)研究結(jié)果近期發(fā)表在Nature Biomedical Engineering期刊上，論文標(biāo)題為“Skeletal muscle regeneration via the chemical induction and expansion of myogenic stem cells in...
9
2018 - 06 - 29
Cell雜志發(fā)文稱，科學(xué)家已發(fā)現(xiàn)3個(gè)幾乎相同的基因可以幫助解釋人類早期祖先的0.5升灰質(zhì)是如何成為1.4升器官的，這一進(jìn)化使得人類這一物種是如此成功和獨(dú)特。另外，新發(fā)現(xiàn)的基因幫助解釋了大腦發(fā)育有時(shí)是如何出錯(cuò)并導(dǎo)致神經(jīng)系統(tǒng)紊亂的。DOI: https://doi.org/10.1016/j.cell.2018.03.051這一新發(fā)現(xiàn)的明星家族——NOTCH2NL，在大腦皮質(zhì)發(fā)育過程中表達(dá)，負(fù)責(zé)促進(jìn)神經(jīng)祖細(xì)胞更新，從而產(chǎn)生更多的神經(jīng)元。NOTCH2NL本身是NOTCH基因家族的一個(gè)分支，后者負(fù)責(zé)調(diào)控所有生物（從過引導(dǎo)鯨魚）的發(fā)育時(shí)間。但是，5月31日發(fā)表在Cell上的兩項(xiàng)研究顯示，在最近的進(jìn)化史中，發(fā)生了一系列“基因事故”，在人類身上產(chǎn)生了4個(gè)非常密切相關(guān)的NOTCH2NL基因?！斑@些基因是一個(gè)古老的發(fā)育基因的后代，在進(jìn)化過程中不斷復(fù)制和改變，從而加入與人腦擴(kuò)大有關(guān)的DNA名單中?！币敶髮W(xué)進(jìn)化基因組學(xué)家James Noonan說，“它們會(huì)增加腦組織中潛在神經(jīng)細(xì)胞的數(shù)量這些新蛋白質(zhì)可能會(huì)以非常強(qiáng)大的方式改變腦部發(fā)育中的重要途徑。”論文一：人類獨(dú)有的NOTCH2NL在猿的祖先中，NOTCH2的復(fù)制產(chǎn)生了一個(gè)非功能性的NOTCH2NL (gray)。修復(fù)和后來的基因復(fù)制產(chǎn)生了多個(gè)拷貝。(GRAPHIC) V. ALTOUNIAN/SCIENCE; (DATA) FIDDES ET AL.,...
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產(chǎn)品名稱： EVOS? Vessel Holder, universal
型號(hào)：
時(shí)間： 2019 - 04 - 15
描述EVOS® vessel holders allow a perfect fit of your microscope slide, cell culture flask or dish, or micro-well plate to the stage of the EVOS® imaging systems for increased precision in sample alignment. This particular vessel holder has a 25.4 mm opening and accommodates most vessel types. It is just one of many easy-to-change vessel holders and stage plates available for this instrument platform. With a snug and secure fit, yet readily switched, these accessories make imaging samp...
型號(hào)：
時(shí)間： 2019 - 04 - 15
描述EVOS® vessel holders allow a perfect fit of your microscope slide, cell culture flask or dish, or micro-well plate to the stage of the EVOS® imaging systems for increased precision in sample alignment. This particular vessel holder accommodates one Greiner T-75 flask. It is just one of many easy-to-change vessel holders and stage plates available for this instrument platform. With a snug and secure fit, yet readily switched, these accessories make imaging samples in a range of ves...
型號(hào)：
時(shí)間： 2019 - 04 - 15
描述EVOS® vessel holders allow a perfect fit of your microscope slide, cell culture flask or dish, or micro-well plate to the stage of the EVOS® imaging systems for increased precision in sample alignment. This particular vessel holder accommodates a hemocytometer. It is just one of many easy-to-change vessel holders and stage plates available for this instrument platform. With a snug and secure fit, yet readily switched, these accessories make imaging samples in a range of vessel hol...
型號(hào)：
時(shí)間： 2019 - 04 - 15
描述EVOS® vessel holders allow a perfect fit of your microscope slide, cell culture flask or dish, or micro-well plate to the stage of the EVOS® imaging systems for increased precision in sample alignment. This particular vessel holder accommodates one Nunc® T-75 flask. It is just one of many easy-to-change vessel holders and stage plates available for this instrument platform. With a snug and secure fit, yet readily switched, these accessories make imaging samples in a range of ...
型號(hào)：
時(shí)間： 2019 - 04 - 15
描述EVOS® vessel holders allow a perfect fit of your microscope slide, cell culture flask or dish, or micro-well plate to the stage of the EVOS® imaging systems for increased precision in sample alignment. This particular vessel holder accommodates two 25 cm T-flasks. It is just one of many easy-to-change vessel holders and stage plates available for this instrument platform. With a snug and secure fit, yet readily switched, these accessories make imaging samples in a range of vessel ...
型號(hào)：
時(shí)間： 2019 - 04 - 15
描述EVOS® vessel holders allow a perfect fit of your microscope slide, cell culture flask or dish, or micro-well plate to the stage of the EVOS® imaging systems for increased precision in sample alignment. This particular vessel holder accommodates one 100 mm Petri dish. It is just one of many easy-to-change vessel holders and stage plates available for this instrument platform. With a snug and secure fit, yet readily switched, these accessories make imaging samples in a range of vess...
型號(hào)：
時(shí)間： 2019 - 04 - 15
描述EVOS® vessel holders allow a perfect fit of your microscope slide, cell culture flask or dish, or micro-well plate to the stage of the EVOS® imaging systems for increased precision in sample alignment. This particular vessel holder accommodates two 60 mm Petri dishes. It is just one of many easy-to-change vessel holders and stage plates available for this instrument platform. With a snug and secure fit, yet readily switched, these accessories make imaging samples in a range of ves...
型號(hào)：
時(shí)間： 2019 - 04 - 12
描述EVOS® vessel holders allow a perfect fit of your microscope slide, cell culture flask or dish, or micro-well plate to the stage of the EVOS® imaging systems for increased precision in sample alignment. This particular vessel holder accommodates four 35 mm Petri dishes. It is just one of many easy-to-change vessel holders and stage plates available for this instrument platform. With a snug and secure fit, yet readily switched, these accessories make imaging samples in a range of ve...
型號(hào)：
時(shí)間： 2019 - 04 - 12
描述EVOS® vessel holders allow a perfect fit of your microscope slide, cell culture flask or dish, or micro-well plate to the stage of the EVOS® imaging systems for increased precision in sample alignment. This particular vessel holder accommodates two 25 x 75 mm slides. It is just one of many easy-to-change vessel holders and stage plates available for this instrument platform. With a snug and secure fit, yet readily switched, these accessories make imaging samples in a range of vess...
型號(hào)：
時(shí)間： 2019 - 04 - 12
描述This fluorite objective is ideal for fluorescence and demanding transmitted-light applications. This is a long working distance (LWD) objective that is optimized for the imaging of slides, cell culture dishes and flasks, and microtiter plates. This is also a phase-contrast objective, making it useful for hard-to-see, translucent speciments. All EVOS® objectives offer outstanding optical performance from visible light to near infrared light. The extensive choice of objectives satisfies nee...
產(chǎn)品名稱： EVOS? Light Cube, Cy?5
型號(hào)：
時(shí)間： 2019 - 04 - 12
描述All EVOS® fluorescence imaging systems and the Countess® II FL Automated Cell Counter contain our unique, proprietary LED light cubes. This world-leading light engine outputs remarkable intensity over a short light path that delivers superior fluorophore excitation. Each cube contains an LED, condensing optics, and hard-coated filters. EVOS® light cubes are user-changeable and automatically recognized by the system. The Cy®5 light cube is ideal for use with Alexa Fluor&...
產(chǎn)品名稱： EVOS? Light Cube, RFP
型號(hào)：
時(shí)間： 2019 - 04 - 12
描述All EVOS® fluorescence imaging systems and the Countess® II FL Automated Cell Counter contain our unique, proprietary LED light cubes. This world-leading light engine outputs remarkable intensity over a short light path that delivers superior fluorophore excitation. Each cube contains an LED, condensing optics, and hard-coated filters. EVOS® light cubes are user-changeable and automatically recognized by the system. The RFP light cube is ideal for use with Alexa Fluor® ...
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